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World J Clin Cases. Apr 16, 2026; 14(11): 119232
Published online Apr 16, 2026. doi: 10.12998/wjcc.v14.i11.119232
Published online Apr 16, 2026. doi: 10.12998/wjcc.v14.i11.119232
Late-onset neurological manifestations of X-linked adrenoleukodystrophy in a male with childhood-onset Addison’s disease: A case report
Pavllo Djamandi, Olga Kyriakou, Ergys Xhukellari, Division of Neurosciences, University Hospital Center Mother Teresa, Tirana 1005, Albania
Hajdi Gorica, Service of Neurology, Trauma University Hospital Center, Tirana 1005, Albania
Arben Rroji, Department of Neuroscience, University of Medicine, Tirana 1000, Albania
Gentian Vyshka, Department of Biomedical and Experimental, Faculty of Medicine, University of Medicine, Tirana 1005, Albania
Author contributions: Djamandi P, Gorica H, Kyriakou O, and Rroji A contributed to manuscript drafting, patient consulting, treatment and follow-up; Djamandi P, Xhukellari E, and Vyshka G contributed to manuscript writing and revising, literature review; and all authors have read and approved the final manuscript.
Informed consent statement: Written informed consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: All authors declare that they have no conflict of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Corresponding author: Gentian Vyshka, MD, Department of Biomedical and Experimental, Faculty of Medicine, University of Medicine, Rr. Dibres 371, Tirana 1005, Albania.
Received: January 23, 2026
Revised: February 12, 2026
Accepted: March 3, 2026
Published online: April 16, 2026
Processing time: 77 Days and 13.7 Hours
Revised: February 12, 2026
Accepted: March 3, 2026
Published online: April 16, 2026
Processing time: 77 Days and 13.7 Hours
Core Tip
Core Tip: Adrenoleukodystrophies are a heterogeneous neurological occurrence and sometimes their differential diagnosis might be difficult. Addison disease among other background conditions might be related to such a progressive disorder that could lead to severe neurological injury. We present a case where the nervous symptomatology was delayed vis-à-vis the initial and main disease, and whose psychiatric signs preceded gait instability, impaired balance, and dysarthria. Imaging and genetic studies are of particular diagnostic importance in this setting.