Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Clin Cases. Apr 6, 2026; 14(10): 118527
Published online Apr 6, 2026. doi: 10.12998/wjcc.v14.i10.118527
Published online Apr 6, 2026. doi: 10.12998/wjcc.v14.i10.118527
Renal granuloma as an extraintestinal manifestation in Crohn’s disease: A case report
Maddison Terlato, Weilun Gao, Leshni Pillay, Jonathan P Segal, Finlay Macrae, Britt Christensen, Department of Gastroenterology and Hepatology, Royal Melbourne Hospital, Melbourne 3050, Victoria, Australia
David Williams, Department of Anatomical Pathology, Austin Health, Melbourne 3084, Vic
Jonathan P Segal, Finlay Macrae, Britt Christensen, Department of Medicine, University of Melbourne, Melbourne 3052, Victoria, Australia
Co-first authors: Maddison Terlato and Weilun Gao.
Author contributions: Terlato M, Gao W, Pillay L, Williams D, Segal JP, Macrae F, and Christensen B contributed to conceptualization, writing - review and editing; Terlato M, Gao W, and Pillay L contributed to investigation; data curation; formal analysis; writing - original draft; Williams D contributed to resources (histopathology expertise); Williams D, Segal JP, Macrae F, and Christensen B contributed to supervision; Terlato M and Gao W contributed equally to this manuscript and are co-first authors.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Corresponding author: Leshni Pillay, MD, Consultant, Doctorate Student, FRACP, Department of Gastroenterology and Hepatology, Royal Melbourne Hospital, 300 Grattan Street, Melb
Received: January 13, 2026
Revised: February 3, 2026
Accepted: March 9, 2026
Published online: April 6, 2026
Processing time: 87 Days and 22.1 Hours
Revised: February 3, 2026
Accepted: March 9, 2026
Published online: April 6, 2026
Processing time: 87 Days and 22.1 Hours
Core Tip
Core Tip: Renal granulomatous inflammation is an exceedingly rare extraintestinal manifestation of Crohn’s disease (CD) and lacks established management guidelines. We report a biopsy-confirmed case of CD-associated renal granuloma with interstitial nephritis demonstrating sustained renal and intestinal response to infliximab therapy. This case underscores the importance of considering immune-mediated renal involvement in CD and suggests that disease-targeted biologic therapy may represent an effective treatment approach for this rare manifestation.