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©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jan 6, 2026; 14(1): 111246
Published online Jan 6, 2026. doi: 10.12998/wjcc.v14.i1.111246
Published online Jan 6, 2026. doi: 10.12998/wjcc.v14.i1.111246
Unfolding the enigma of familial Hodgkin lymphoma: Current insights
Jelena Roganovic, Nusa Matijasic Stjepovic, Department of Pediatric Oncology and Hematology, Children’s Hospital Zagreb, Zagreb 10000, Croatia
Jelena Roganovic, Faculty of Biotechnology and Drug Development, University of Rijeka, Rijeka 51000, Croatia
Ana Dordevic, Department of Business Development, Jadran Galenski Laboratorij, Rijeka 51000, Croatia
Author contributions: Roganovic J and Matijasic Stjepovic N designed the study; Matijasic Stjepovic N collected the data, performed the research and wrote the preliminary draft; Dordevic A reviewed the literature and provided the technical support in preparing and submission of the manuscript; Roganovic J contributed to writing and made critical revisions to the manuscript for important intellectual content; All authors have read and approved the final version of the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jelena Roganovic, PhD, MD, Tenured Professor, Department of Pediatric Oncology and Hematology, Children’s Hospital Zagreb, Klaiceva 16, Zagreb 10000, Croatia. jelena.roganovic02@gmail.com
Received: June 30, 2025
Revised: August 1, 2025
Accepted: December 22, 2025
Published online: January 6, 2026
Processing time: 192 Days and 21.7 Hours
Revised: August 1, 2025
Accepted: December 22, 2025
Published online: January 6, 2026
Processing time: 192 Days and 21.7 Hours
Core Tip
Core Tip: Hodgkin lymphoma (HL), although rare, is one of the most common pediatric malignancies. Familial clustering points to genetic susceptibility, especially in young-onset cases. Recently, whole-genome sequencing studies of affected families have identified several predisposing genetic variants, contributing to unraveling the complex etiopathogenesis of HL. New insights into tumor biology and the identification of germline mutations may facilitate genetic counselling, raising awareness among first-degree relatives of HL patients about potential symptoms and leading to earlier diagnosis and better outcomes. Emphasizing that the hereditary risk of HL remains low can provide significant psychological relief for affected families.