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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Dec 26, 2025; 13(36): 111835
Published online Dec 26, 2025. doi: 10.12998/wjcc.v13.i36.111835
Published online Dec 26, 2025. doi: 10.12998/wjcc.v13.i36.111835
Primary ileal squamous cell carcinoma: A case report and review of literature
Qian-Qian Li, Lu-Yao Fang, Huan-Fen Zhao, Department of Pathology, Hebei General Hospital, Shijiazhuang 050051, Hebei Province, China
Jie Wei, Jia-Lv Zhou, Department of Pathology, Graduate School of North China University of Science and Technology, Tangshan 063210, Hebei Province, China
Author contributions: Li QQ and Wei J contributed to manuscript writing, editing, and data collection; Fang LY and Zhou JL contributed to data analysis; Zhao HF contributed to conceptualization and supervision. All authors read and approved the final version of the manuscript.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Huan-Fen Zhao, Chief Physician, Professor, Department of Pathology, Hebei General Hospital, No. 348 Heping West Road, Shijiazhuang 050051, Hebei Province, China. hbghbinglike@126.com
Received: July 11, 2025
Revised: September 22, 2025
Accepted: December 15, 2025
Published online: December 26, 2025
Processing time: 168 Days and 4.9 Hours
Revised: September 22, 2025
Accepted: December 15, 2025
Published online: December 26, 2025
Processing time: 168 Days and 4.9 Hours
Core Tip
Core Tip: Primary ileal squamous cell carcinoma represents a paradox, as it arises in the ileal mucosa that lacks native squamous epithelium. With an incidence of less than 0.001% among intestinal malignancies and only 12 confirmed cases worldwide (as of 2025), this rare entity remains poorly characterized in the literature. Here, we report a newly diagnosed case of primary ileal squamous cell carcinoma and synthesize its clinicopathologic features, clinical presentation, therapeutic management, and the patient’s outcome and prognosis, with particular emphasis on diagnostic dilemmas and treatment efficacy.