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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Dec 16, 2025; 13(35): 112965
Published online Dec 16, 2025. doi: 10.12998/wjcc.v13.i35.112965
Published online Dec 16, 2025. doi: 10.12998/wjcc.v13.i35.112965
Risk of incident pancreatitis in patients with celiac disease: A population-based matched retrospective cohort study
Arunkumar Krishnan, Diptasree Mukherjee, Department of Supportive Oncology, Atrium Health Levine Cancer, Charlotte, NC 28204, United States
Arunkumar Krishnan, Department of Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157, United States
Daniel Teran, Department of Medicine, West Virginia University School of Medicine, Mor
Author contributions: Krishnan A contributed to the concept of the study and study design and was responsible for data acquisition and statistical analysis; Krishnan A drafted the manuscript; Krishnan A, Teran D, and Mukherjee D participated in the review and editing. All authors were involved with interpreting the data and critically revising the manuscript for important intellectual content. All authors reviewed and approved the final version of the manuscript.
Institutional review board statement: TriNetX data have been granted a waiver from the Western Institutional Review Board as a federated network, as only aggregated counts and statistical summaries of de-identified information are used.
Informed consent statement: Not applicable for de-identified data.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Arunkumar Krishnan, Department of Supportive Oncology, Atrium Health Levine Cancer, 1021 Morehead Medical Drive, Suite 70100, Charlotte, NC 28204, United States. dr.arunkumar.krishnan@gmail.com
Received: August 11, 2025
Revised: September 16, 2025
Accepted: December 10, 2025
Published online: December 16, 2025
Processing time: 127 Days and 7.6 Hours
Revised: September 16, 2025
Accepted: December 10, 2025
Published online: December 16, 2025
Processing time: 127 Days and 7.6 Hours
Core Tip
Core Tip: Celiac disease (CD) is an immune-mediated disorder with well-recognized gastrointestinal and extraintestinal manifestations. However, limited large-scale studies have evaluated its association with pancreatic disease. We investigated the long-term risk of acute and chronic pancreatitis in a large, propensity score-matched cohort of patients with CD. CD was associated with a significantly higher risk of pancreatitis, including alcohol-related, biliary, and idiopathic subtypes, com