Elevated body mass index as a prognostic marker in acute liver failure: Implications from a two-decade cohort

doi:10.12998/wjcc.v13.i34.113129

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Dec 6, 2025 (publication date) through Dec 9, 2025

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World Journal of Clinical Cases

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2307-8960

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Cases. Dec 6, 2025; 13(34): 113129
Published online Dec 6, 2025. doi: 10.12998/wjcc.v13.i34.113129

Elevated body mass index as a prognostic marker in acute liver failure: Implications from a two-decade cohort

Shree Rath

Shree Rath, Department of Medicine, All India Institute of Medical Sciences Bhubaneswar, Bhubaneswar 751019, Odisha, India

Author contributions: Rath S was responsible for conceptualization, data curation, writing and review of the manuscript.

Conflict-of-interest statement: The authors report no relevant conflicts of interest for this article.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Shree Rath, MD, Department of Medicine, All India Institute of Medical Sciences Bhubaneswar, Sijua, Patrapada, Bhubaneswar 751019, Odisha, India. shreerath4a@gmail.com

Received: August 18, 2025
Revised: September 14, 2025
Accepted: November 21, 2025
Published online: December 6, 2025
Processing time: 111 Days and 22.3 Hours

Core Tip

Core Tip: The association between elevated body mass index (BMI) and poor outcomes in acute liver failure (ALF) has been underexplored in recent literature. Krishnan et al present a large, two-decade United States cohort showing that overweight and obese patients face a twofold higher risk of death or need for liver transplantation, along with greater prevalence of severe hepatic encephalopathy and renal dysfunction. These findings highlight BMI as an important prognostic marker in ALF and support its integration into risk assessment frameworks. Targeted monitoring and early interventions in this population may help mitigate adverse outcomes.