Copyright
©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Nov 26, 2025; 13(33): 113751
Published online Nov 26, 2025. doi: 10.12998/wjcc.v13.i33.113751
Published online Nov 26, 2025. doi: 10.12998/wjcc.v13.i33.113751
Disseminated herpes simplex virus type 1 treated with ixekizumab in a patient with erythrodermic psoriasis: A case report
Ahmad Berjawi, Zeina Tannous, Department of Dermatology, Lebanese American University, Beirut 1100, Beyrouth, Lebanon
Rana Attieh, Marcella Younes, Department of Internal Medicine, Lebanese American University, Beirut 1100, Beyrouth, Lebanon
Karen Beydoun, Department of Internal Medicine, Saint Georges University of Beirut, Beirut 1100, Beyrouth, Lebanon
Issam Fassih, Department of Internal Medicine, University of Balamand, Beirut 1100, Beyrouth, Lebanon
Author contributions: Berjawi A, Attieh R, Younes M, Beydoun K, Fassih I, Tannous Z contributed to acquisition and interpretation of clinical data, drafting and revising the manuscript for important intellectual content, final approval of the version to be published; all authors agree to be accountable for all aspects of the work.
Informed consent statement: Written informed consent was obtained from the patient for publication of this case report and the accompanying images.
Conflict-of-interest statement: All authors declare that there is no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Issam Fassih, MD, Department of Internal Medicine, University of Ba
Received: September 2, 2025
Revised: September 24, 2025
Accepted: October 28, 2025
Published online: November 26, 2025
Processing time: 80 Days and 8.1 Hours
Revised: September 24, 2025
Accepted: October 28, 2025
Published online: November 26, 2025
Processing time: 80 Days and 8.1 Hours
Core Tip
Core Tip: Erythrodermic psoriasis (EP) is a rare, severe form of psoriasis associated with high morbidity and mortality. Management frequently requires systemic immunosuppression, which increases susceptibility to opportunistic infections. We describe a patient with EP who developed disseminated herpes simplex virus type 1 while receiving biologic and corticosteroid therapy. This case emphasizes the importance of early recognition of vesicular eruptions, timely diagnostic testing, and prompt antiviral therapy. Clinicians must balance disease control with infection risk, highlighting the need for vigilant monitoring and multidisciplinary management in EP.