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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Nov 16, 2025; 13(32): 104208
Published online Nov 16, 2025. doi: 10.12998/wjcc.v13.i32.104208
Published online Nov 16, 2025. doi: 10.12998/wjcc.v13.i32.104208
Rethinking p16, p53, and HPV in HNCSCC through lessons from glioblastoma subclonal evolution toward patient-centric N-of-1 single-cell RNA sequencing paradigm
Henry Michael Lee, Shengwen Calvin Li, Department of Neurology, University of California-Irvine School of Medicine, Orange, CA 92868, United States
Co-first authors: Henry Michael Lee and Shengwen Calvin Li.
Author contributions: Lee HM and Li SC contribute conceptually and in writing, they contributed equally to this manuscript and are co-first authors.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Shengwen Calvin Li, PhD, Department of Neurology, University of California-Irvine School of Medicine, 1001 Health Sciences Road, Orange, CA 92868, United States. sli@choc.org
Received: December 16, 2024
Revised: August 29, 2025
Accepted: October 15, 2025
Published online: November 16, 2025
Processing time: 334 Days and 8.9 Hours
Revised: August 29, 2025
Accepted: October 15, 2025
Published online: November 16, 2025
Processing time: 334 Days and 8.9 Hours
Core Tip
Core Tip: Nam et al’s article provides a compelling investigation into the mysterious interaction between human papillomavirus, p16, and p53 in Asian populations. This investigation is part of the investigation into the pathogenesis and prognosis of cancer. The results of this study not only contribute to our expansion of knowledge regarding head and neck cutaneous squamous cell carcinoma, but they also question our preconceived assumptions regarding biomarkers that have traditionally been associated with positive outcomes.