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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Nov 6, 2025; 13(31): 112023
Published online Nov 6, 2025. doi: 10.12998/wjcc.v13.i31.112023
Published online Nov 6, 2025. doi: 10.12998/wjcc.v13.i31.112023
Mantle cell lymphoma presenting primarily as cutaneous lesions: A case report
Pei-Yu Zhou, Wei Chen, Lin Wang, Department of Dermatology, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China
Author contributions: Zhou PY drafted and proofread the manuscript; Chen W and Wang L edited the manuscript; Wang L determined the theme and innovation; All authors have agreed upon the submission and publication of this work; All authors reviewed the manuscript.
Supported by the Department of Science and Technology of Sichuan Province, No. 2023NSFSC0724.
Informed consent statement: Informed consent was taken from the patient for publishing the data.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Lin Wang, PhD, Chief Physician, Department of Dermatology, West China Hospital of Sichuan University, No. 7 Renmin Nanlu San Duan, Wuhou District, Cheng
Received: July 16, 2025
Revised: July 28, 2025
Accepted: September 12, 2025
Published online: November 6, 2025
Processing time: 106 Days and 20.6 Hours
Revised: July 28, 2025
Accepted: September 12, 2025
Published online: November 6, 2025
Processing time: 106 Days and 20.6 Hours
Core Tip
Core Tip: Mantle cell lymphoma (MCL) is an aggressive subtype of B-cell lymphoma that rarely involves the skin. When cutaneous involvement occurs, it often indicates advanced systemic disease and is associated with a poor prognosis. This case emphasizes the difficulty in differentiating cutaneous MCL from other similar lymphomas, such as diffuse large B-cell lymphoma, leg-type. Accurate diagnosis relies heavily on immunophenotypic markers, particularly cyclin D1 and SOX11. Therefore, a comprehensive approach integrating clinical findings, histopathology, and molecular studies is vital for timely diagnosis, appropriate treatment, and improved patient outcomes.