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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Oct 26, 2025; 13(30): 109701
Published online Oct 26, 2025. doi: 10.12998/wjcc.v13.i30.109701
Published online Oct 26, 2025. doi: 10.12998/wjcc.v13.i30.109701
Revitalizing liver health: Human placental extract shows promise in chronic liver disease management
Yang Liu, The First Clinical Medical School, Gansu University of Chinese Medicine, Lanzhou 730000, Gansu Province, China
Yan Wang, Division of Personnel, Gansu Provincial People’s Hospital, Lanzhou 730000, Gansu Province, China
Xiao-Jun Yang, Department of General Surgery, Gansu Provincial People’s Hospital, Lanzhou 730000, Gansu Province, China
Co-first authors: Yang Liu and Yan Wang.
Author contributions: Liu Y conceived and outlined the manuscript; Wang Y participated in the discussion and design of the manuscript; Yang XJ contributed to the writing, and editing the manuscript.
Supported by PhD Supervisor Training Program, No. 22GSSYA-3; Gansu Provincial Health Industry Research Project, No. GSWSKY2020-45; and Gansu Natural Science Foundation, No. 20JR10RA378.
Conflict-of-interest statement: All the authors of this article declare that they have no relevant conflicts of interest.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiao-Jun Yang, MD, PhD, Professor, Department of General Surgery, Gansu Provincial People’s Hospital, No. 199 Donggang West Road, Chengguan District, Lanzhou 730000, Gansu Province, China. yangxjmd@aliyun.com
Received: May 19, 2025
Revised: June 18, 2025
Accepted: August 15, 2025
Published online: October 26, 2025
Processing time: 145 Days and 21.2 Hours
Revised: June 18, 2025
Accepted: August 15, 2025
Published online: October 26, 2025
Processing time: 145 Days and 21.2 Hours
Core Tip
Core Tip: An innovative intervention involving intravenous injection of human placental extract was introduced in a recent case report from Danann Medical Clinic, which aimed to improve the liver functions of chronic liver disease patients. However, the study was restricted by the issues, including a small sample size, absence of a control group, and insufficient long-term safety data, and the mechanistic underpinnings and generalizability of therapeutic efficacy required further validation.