Diagnostic accuracy of circulating miR-146, miR-221 and miR-222 in papillary thyroid cancer: A systematic review and meta-analysis

doi:10.12998/wjcc.v13.i27.104916

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World Journal of Clinical Cases

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2307-8960

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Cases. Sep 26, 2025; 13(27): 104916
Published online Sep 26, 2025. doi: 10.12998/wjcc.v13.i27.104916

Diagnostic accuracy of circulating miR-146, miR-221 and miR-222 in papillary thyroid cancer: A systematic review and meta-analysis

Benjamin Dean, Georgios Geropoulos, Toby Richardson-Jones, Massimiliano Fornasiero, Michail Papapanou, Christos Konstantinidis, Nikolaos Madouros, Dimitrios Spinos, Georgios Koimtzis, Dimitrios Giannis, Christos Athanasiou, Kyriakos Psarras

Benjamin Dean, Georgios Geropoulos, Department of Transplant Surgery, Cambridge University Hospitals, Cambridge CB20QQ, Cambridgeshire, United Kingdom

Benjamin Dean, Toby Richardson-Jones, Medical School, University of Bristol, Bristol BS81QU, United Kingdom

Massimiliano Fornasiero, Medical School, University College London Hospitals, London HA90UL, London, United Kingdom

Michail Papapanou, Second Department of Obstetrics and Gynecology, Medical School, National Kapodistrian University of Athens, Athens 45600, Attikí, Greece

Christos Konstantinidis, Surgical Group, Society of Junior Doctors, Athens 45300, Attikí, Greece

Nikolaos Madouros, Department of Neurosurgery, University College London Hospitalsrs, London HA90OL, United Kingdom

Dimitrios Spinos, Department of Ear, Nose and Throat Surgery, University Hospitals of Birmingham, Birmingham B170NN, United Kingdom

Georgios Koimtzis, Cardiff Transplant Unit, University Hospital of Wales, Cardiff and Vale University Health Board, Cardiff CF144XW, United Kingdom

Dimitrios Giannis, Institute of Health Innovations and Outcomes Research, Feinstein Institutes for Medical Research, Manhasset, NY 11030, United States

Christos Athanasiou, Cambridge University Hospitals, Cambridge University Hospitals NHS Foundation Trust, Cambridge CB34NT, Cambridgeshire, United Kingdom

Kyriakos Psarras, Laboratory of Scientific Research and Experimental Surgery, 2nd Propedeutic Department of Surgery, School of Medicine, Aristotle University, Thessaloniki 54642, Greece

Co-first authors: Benjamin Dean and Georgios Geropoulos.

Author contributions: Dean B, Geropoulos G and Giannis D conceptualized the idea and prepared the first draft; Richardson-Jones T, Fornasiero M, Papapanou M, Konstantinidis C and Madouros N perform the literature search; Geropoulos G, Giannis D, Spinos D and Psarras K critically reviewed the draft and prose the changes; Geropoulos G, Giannis D, Koimtzis G and Athanasiou C prepared the final manuscript and submitted; All authors thoroughly reviewed and endorsed the final manuscript.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

PRISMA 2009 Checklist statement: The authors have read the PRISMA 2020 Checklist, and the manuscript was prepared and revised according to the PRISMA 2020 Checklist.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Dimitrios Giannis, MD, MSc, Institute of Health Innovations and Outcomes Research, Feinstein Institutes for Medical Research, 350 Community Dr, Manhasset, NY 11030, United States. dgiannis@northwell.edu

Received: January 17, 2025
Revised: March 25, 2025
Accepted: July 2, 2025
Published online: September 26, 2025
Processing time: 200 Days and 9.9 Hours

Core Tip

Core Tip: While miRNA levels are strongly associated with papillary thyroid cancer (PTC), no consensus has been reached on their diagnostic accuracy for the condition. This is the first systematic review and meta-analysis assessing statistical strength of miRNA in the diagnosis and staging of PTC. We found that miRNA-146 and miRNA-222 were most sensitive, validating their efficacy in PTC diagnosis.