Case Report
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jul 6, 2025; 13(19): 102212
Published online Jul 6, 2025. doi: 10.12998/wjcc.v13.i19.102212
Chronic hepatitis B triggering antineutrophil cytoplasmic antibody-associated vasculitis complicated by glomerulonephritis: A case report
Ming-Ru Li, Li-Ya Li, Juan Tang, Jian Sun
Ming-Ru Li, Jian Sun, Department of Nephrology and Rheumatology, The Third Xiangya Hospital, Central South University, Changsha 410013, Hunan Province, China
Li-Ya Li, Department of Rheumatology and Immunology, Xiangya Hospital of Central South University, Changsha 410013, Hunan Province, China
Juan Tang, Department of Nephrology, Central South University, Changsha 410013, Hunan Province, China
Author contributions: Li MR collected the materials and drafted the manuscript; Li LY and Tang J revised the content of the manuscript; Sun J contributed to critically revising the manuscript for important intellectual content and offered unique insights into the clinical data and valuable suggestions for improving the manuscript; and all authors gave final approval for the version to be submitted.
Supported by the Natural Science Foundation of Hunan Province, China, No. 2023JJ30842.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jian Sun, Chief Physician, MD, PhD, Professor, Department of Nephrology and Rheumatology, The Third Xiangya Hospital, Central South University, No. 138 Tongzipo Road, Changsha 410013, Hunan Province, China. sunjian105@sina.com
Received: October 11, 2024
Revised: January 19, 2025
Accepted: February 28, 2025
Published online: July 6, 2025
Processing time: 158 Days and 13.8 Hours
Core Tip

Core Tip: This case highlights a 63-year-old man diagnosed with hepatitis B virus-related nephropathy complicated by antineutrophil cytoplasmic antibody-associated vasculitis. Despite undergoing treatments such as plasma exchange, protein A immunoadsorption, and immune modulation, the patient suffered dual renal insults, necessitating maintenance dialysis and resulting in a poor prognosis. Chronic hepatitis B virus infection may contribute to antineutrophil cytoplasmic antibody production, emphasizing the importance of early diagnosis and proactive clearance of immune complexes to improve outcomes in similar cases.