Case Report
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Mar 6, 2024; 12(7): 1326-1332
Published online Mar 6, 2024. doi: 10.12998/wjcc.v12.i7.1326
Misdiagnosis of synovial sarcoma - cellular myofibroma with SRF-RELA gene fusion: A case report
Ying Zhou, Yi-Wen Sun, Xiao-Yang Liu, Dan-Hua Shen
Ying Zhou, Yi-Wen Sun, Xiao-Yang Liu, Dan-Hua Shen, Department of Pathology, Peking University People’s Hospital, Beijing 100044, China
Author contributions: Zhou Y and Sun YW designed the research study; Zhou Y, Sun YW and Liu XY performed the research; Zhou Y and Shen DH wrote the manuscript; All authors have read and approved the final manuscript.
Informed consent statement: Written informed consent has been obtained from the patient for publication of this case report.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Dan-Hua Shen, MD, Chief Physician, Department of Pathology, Peking University People's Hospital, No. 11 Xizhimen South Street, Beijing 100044, China. shendanhua@pkuph.edu.cn
Received: November 11, 2023
Peer-review started: November 11, 2023
First decision: December 26, 2023
Revised: January 6, 2024
Accepted: January 25, 2024
Article in press: January 25, 2024
Published online: March 6, 2024
Processing time: 110 Days and 22.6 Hours
Core Tip

Core Tip: Cellular myofibroma (CMF) is a rare subtype of myofibroma that exhibits a broad age distribution, and manifests in diverse anatomical locations, including deep soft tissues and skeletal muscles. Owing to the absence of distinct features, CMF is frequently misdiagnosed. Microscopic examination revealed active mitotic figures (non-pathological), focal areas of necrosis, and occasional infiltrative growth. Next-generation sequencing aids in the accurate pathological diagnosis of CMF by detecting the SRF-RELA gene fusion.