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©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Oct 26, 2024; 12(30): 6374-6382
Published online Oct 26, 2024. doi: 10.12998/wjcc.v12.i30.6374
Published online Oct 26, 2024. doi: 10.12998/wjcc.v12.i30.6374
Hematological picture of pediatric Sudanese patients with visceral leishmaniasis and prediction of leishmania donovani parasite load
Zeinab Ibrahim Ahmed Elnoor, Department of Pathology, Faculty of Medicine, Omdurman Ahilia University, Omdurman, Khartoum, Sudan
Zeinab Ibrahim Ahmed Elnoor, Mohammed Alamin Hamid Pediatric Hospital, Omdurman Khartoum, Sudan
Zeinab Ibrahim Ahmed Elnoor, Department of Hematology and Blood Transfusion Medicine, Federal Ministry of Health, Khartoum, Sudan
Omaima Abdelmajeed, Department of Pediatrics, Faculty of Medicine, Omdurman Islamic University, Omdurman, Khartoum, Sudan
Omaima Abdelmajeed, Tropical Diseases Teaching Hospital, Omdurman, Khartoum, Sudan
Alamin Mustafa, Shima Algam Mohamed Musa, Abdelrahman Hamza Abdelmoneim, Faculty of Medicine, Al-Neelain University, Khartoum, Sudan
Thuraya Gasim, Faculty of Medicine, Omdurman Islamic University, Omdurman, Khartoum, Sudan
Islamia Ibrahim Ahmed Omer, Department of Pediatrics, Faculty of Medicine, University of Science and Technology, Khartoum, Sudan
Hiba Awadelkareem Osman Fadl, Department of Hematology, Faculty of Medical Laboratory Sciences, Al-Neelain University, Khartoum, Sudan
Author contributions: Elnoor ZI, Salih O A approved the study and collected the data; Mustafa A, Omer II, Salih OA, Fadl HA, Musa SA, and Elnoor ZI took the lead in writing the manuscript; Mustafa A analyzed the data and interpreted the results; Omer II, Gassim T, Musa SA, Abdelmoneim AH, and Fadl HA wrote and revised the manuscript; All authors reviewed the manuscript, provided critical feedback, and agreed on the final manuscript.
Institutional review board statement: We obtained written ethical approval from the Tropical Disease Teaching Hospital administrative authority (TDTH/B/51/1 data: 1st Jan 2021). The information acquired was kept confidential and only utilized in the context of this study.
Informed consent statement: Informed consent statement was inapplicable in retrospective study.
Conflict-of-interest statement: All the authors declare that they have no conflict of interest.
Data sharing statement: Data are available upon request to the corresponding author.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Alamin Mustafa, Doctor, Researcher, Statistical Worker, Faculty of Medicine, Al-Neelain University, 52nd St, Khartoum, Sudan. alamin900005@gmail.com
Received: March 9, 2024
Revised: July 14, 2024
Accepted: August 16, 2024
Published online: October 26, 2024
Processing time: 178 Days and 20.1 Hours
Revised: July 14, 2024
Accepted: August 16, 2024
Published online: October 26, 2024
Processing time: 178 Days and 20.1 Hours
Core Tip
Core Tip: Visceral leishmaniasis (VL) is a neglected tropical disease; although many parts of Sudan are hyperendemic, many centers have very limited diagnostic capabilities and data reporting. This is one of the first studies from Sudan to investigate both hematological and bone marrow changes associated with pediatric VL and Leishmania donovani load from bone marrow biopsies. The data were collected from tertiary and specialized centers for treating VL in the country and modern analytical methods were used to describe the result for the global audience and highlight the importance of these new findings derived from a country that is hyperendemic to VL.