Case Report
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Oct 6, 2024; 12(28): 6222-6229
Published online Oct 6, 2024. doi: 10.12998/wjcc.v12.i28.6222
Recurrent multisystem Langerhans cell histiocytosis involving the female genitalia: A case report
Chun-Yan Yuan, Zhi-Rong Zhang, Ming-Fang Guo, Na Zhang
Chun-Yan Yuan, Zhi-Rong Zhang, Department of Gynaecology, Fengdu People's Hospital, Chongqing 408200, China
Ming-Fang Guo, Na Zhang, Department of Gynecologic Oncology, Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer Hospital, Chongqing Cancer Institute, Chongqing Cancer Hospital, Chongqing 400030, China
Co-corresponding authors: Ming-Fang Guo and Na Zhang.
Author contributions: Yuan CY and Zhang ZR were involved in data collection; Zhang N and Guo MF were involved in the supervision of the study and conceptualized and designed the research; Zhang N and Guo MF performed data analysis; Yuan CY, Zhang N and Guo MF wrote the paper; Guo MF applied for and obtained the funds for this research project. Guo MF conceptualized, designed, and supervised the whole process of the project. Zhang N was instrumental and responsible for data re-analysis and re-interpretation, figure plotting, comprehensive literature search, preparation and submission of the current version of the manuscript. Both Zhang N and Guo MF have played important and indispensable roles in the experimental design, data interpretation and manuscript preparation as the co-corresponding authors. This collaboration between Zhang N and Guo MF is crucial for the publication of this manuscript and other manuscripts still in preparation. And all authors have reviewed the final version to be published and agreed to be accountable for all aspects of the work.
Supported by the Chongqing Science and Health Committee Joint Medical Scientific Research General Project, No. 2021MSXM236; and the Health Development Promotion Project, No. BJHA-CRP-086.
Informed consent statement: The study participant provided informed written consent prior to study registration.
Conflict-of-interest statement: All authors declare that they have no conflict of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Na Zhang, MM, Doctor, Department of Gynecologic Oncology, Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer Hospital, Chongqing Cancer Institute, Chongqing Cancer Hospital, No. 181 Hanyu Road, Shapingba District, Chongqing 400030, China. zhang_zhang07@163.com
Received: March 23, 2024
Revised: May 20, 2024
Accepted: June 20, 2024
Published online: October 6, 2024
Processing time: 142 Days and 15.6 Hours
Core Tip

Core Tip: The pathogenesis of Langerhans cell histiocytosis (LCH) is unclear and it is currently classified as a neoplastic disease. Recurrent LCH involving the female genitalia is rare. Pathological diagnosis is considered the gold standard. For patients with extensive lesions or relapses, we recommend a hematology-based multidisciplinary diagnostic and treatment model. New combination chemotherapy regimens and maintenance chemotherapy may result in better clinical outcomes.