Observational Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Mar 26, 2023; 11(9): 1963-1973
Published online Mar 26, 2023. doi: 10.12998/wjcc.v11.i9.1963
Clinicopathological features and expression of regulatory mechanism of the Wnt signaling pathway in colorectal sessile serrated adenomas/polyps with different syndrome types
Dan Qiao, Xiao-Yan Liu, Lie Zheng, Ya-Li Zhang, Ren-Ye Que, Bing-Jing Ge, Hong-Yan Cao, Yan-Cheng Dai
Dan Qiao, Xiao-Yan Liu, Ren-Ye Que, Bing-Jing Ge, Hong-Yan Cao, Yan-Cheng Dai, Department of Gastroenterology, Shanghai Traditional Chinese Medicine-Integrated Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200082, China
Lie Zheng, Department of Gastroenterology, Traditional Chinese Medicine Hospital of Xi’an, Xi’an 730000, Shaanxi Province, China
Ya-Li Zhang, Institute of Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
Author contributions: Qiao D and Liu XY contributed equally to this work, and both collected cases and analyzed data; Zheng L and Zhang YL performed pathological examination; Que RY, Ge BJ, and Cao HY prepared the figures and tables; Qiao D and Dai YC wrote and reviewed the manuscript; Dai YC conceived and supervised the study; all authors contributed to the article and approved the submitted version.
Supported by the National Natural Science Foundation of China, No. 81873253; the Shanghai Natural Science Foundation, No. 22ZR1458800; the Hongkou District Health Committee, No. HKZK2020A01; and the Xinglin Scholar Program of Shanghai University of Traditional Chinese Medicine, No. [2020]23.
Institutional review board statement: The Ethics Committee of Shanghai Traditional Chinese Medicine-Integrated Hospital (2020-091-1) approved the experimental protocol.
Conflict-of-interest statement: All authors declare that they have no conflicts of interest.
Data sharing statement: The data analyzed during this study can be obtained from the corresponding author upon reasonable request.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yan-Cheng Dai, PhD, Associate Chief Physician, Department of Gastroenterology, Shanghai Traditional Chinese Medicine-Integrated Hospital, Shanghai University of Traditional Chinese Medicine, No. 230 Baoding Road, Hongkou District, Shanghai 200082, China. daiyancheng2005@126.com
Received: November 22, 2022
Peer-review started: November 22, 2022
First decision: February 7, 2023
Revised: February 12, 2023
Accepted: March 3, 2023
Article in press: March 3, 2023
Published online: March 26, 2023
Processing time: 115 Days and 4.5 Hours
Core Tip

Core Tip: We aimed to observe the difference in the Wnt signaling pathway expression in sessile serrated adenoma/polyp patients with large intestine damp-heat (Da-Chang-Shi-Re) syndrome and spleen-stomach weakness (Pi-Wei-Xu-Ruo) syndrome. We observed that patients with Da-Chang-Shi-Re syndrome had a more obvious Wnt signaling pathway activation and a higher risk of carcinogenesis. A high-quality colonoscopic diagnosis was essential. The thorough assessment of clinical diseases can be improved by combining the diseases of Western medicine with the syndromes of traditional Chinese medicine.