Review
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. May 6, 2023; 11(13): 2874-2889
Published online May 6, 2023. doi: 10.12998/wjcc.v11.i13.2874
Burden of severe infections due to carbapenem-resistant pathogens in intensive care unit
Maria Caterina Pace, Antonio Corrente, Maria Beatrice Passavanti, Pasquale Sansone, Stephen Petrou, Sebastiano Leone, Marco Fiore
Maria Caterina Pace, Antonio Corrente, Maria Beatrice Passavanti, Pasquale Sansone, Marco Fiore, Department of Women, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples 80138, Italy
Stephen Petrou, Department of Emergency Medicine, University of California San Francisco, San Francisco, CA 94143, United States
Sebastiano Leone, Division of Infectious Diseases, “San Giuseppe Moscati” Hospital, Avellino 83100, Italy
Author contributions: Corrente A and Marco F designed the study and performed the research; Pace MC, Passavanti MB, Sansone P and Leone S supervised the manuscript; Petrou S provided critical reviews and revised the Language; Corrente A and Fiore M wrote the manuscript.
Conflict-of-interest statement: The authors have nothing to disclose.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Marco Fiore, MD, Doctor, Department of Women, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Piazza Luigi Miraglia, 2, Naples 80138, Italy. marco.fiore@unicampania.it
Received: December 29, 2022
Peer-review started: December 29, 2022
First decision: January 17, 2023
Revised: February 17, 2023
Accepted: April 4, 2023
Article in press: April 4, 2023
Published online: May 6, 2023
Processing time: 116 Days and 20.9 Hours
Core Tip

Core Tip: Intensive care units for various reasons have become "the epicenter" of nosocomial infections due to multidrug-resistant organisms: a perfect combination of critically ill patients and multidrug-resistant organisms, as the cause of infection, makes these patients' mortality very high. This comprehensive review aims to outline the problem from the clinician's perspective, focusing on the new definition and epidemiology of the most common multidrug-resistant organisms that are Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacterales to emphasize the importance of the problem.