Amebic liver abscess by Entamoeba histolytica

doi:10.12998/wjcc.v10.i36.13157

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World Journal of Clinical Cases

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World J Clin Cases. Dec 26, 2022; 10(36): 13157-13166
Published online Dec 26, 2022. doi: 10.12998/wjcc.v10.i36.13157

Amebic liver abscess by Entamoeba histolytica

Daisuke Usuda, Shiho Tsuge, Riki Sakurai, Kenji Kawai, Shun Matsubara, Risa Tanaka, Makoto Suzuki, Hayabusa Takano, Shintaro Shimozawa, Yuta Hotchi, Shungo Tokunaga, Ippei Osugi, Risa Katou, Sakurako Ito, Kentaro Mishima, Akihiko Kondo, Keiko Mizuno, Hiroki Takami, Takayuki Komatsu, Jiro Oba, Tomohisa Nomura, Manabu Sugita

Takayuki Komatsu, Department of Sports Medicine, Faculty of Medicine, Juntendo University, Bunkyo 113-8421, Tokyo, Japan

Author contributions: Usuda D wrote the manuscript; Tsuge S, Sakurai R, Kawai K, Matsubara S, Tanaka R, Suzuki M, Shimozawa S, Takano H, Hotchi Y, Tokunaga S, Osugi I, Katou R, Ito S, Asako S, Mishima K, Kondo A, Mizuno K, Takami H, Komatsu T, Oba J, Nomura T, and Sugita M proofread and revised the manuscript; All authors approved the final version to be published.

Conflict-of-interest statement: The authors declare that they have no conflicts of interest.

Corresponding author: Daisuke Usuda, MD, MSc, PhD, Associate Professor, Doctor, Senior Lecturer, Staff Physician, Department of Emergency and Critical Care Medicine, Juntendo University Nerima Hospital, 3-1-10, Takanodai, Nerima 177-8521, Tokyo, Japan. d.usuda.qa@juntendo.ac.jp

Received: August 7, 2022
Peer-review started: August 7, 2022
First decision: October 17, 2022
Revised: November 1, 2022
Accepted: December 8, 2022
Article in press: December 8, 2022
Published online: December 26, 2022
Processing time: 141 Days and 18 Hours

Core Tip

Core Tip: Amebic liver abscesses are the most commonly encountered extraintestinal manifestation of human invasive amebiasis, which results from Entamoeba histolytica. It breaches the host’s innate defenses and invades the intestinal mucosa. Trophozoites enter the circulatory system and are filtered in the liver and produce abscesses. The diagnostics primarily aim to use PCR or enzyme-linked immunosorbent assay to detect Entamoeba histolytica. Medical treatment of amebic liver abscesses is possible using an amebicidal drug and a luminal cysticidal agent. Prognoses are generally good. Elucidating the detailed pathogenesis and establishing which diagnostic methods are most efficacious will necessitate further analyses of similar clinical cases.