Molecular mechanisms of Baihedihuang decoction as a treatment for breast cancer related anxiety: A network pharmacology and molecular docking study

doi:10.12998/wjcc.v10.i33.12104

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 10, Issue 33

This Article

Peer-Review Report of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (5912)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Figures (1-7) series, Tables (1-2) series.

Item

Count

PDF

296

WORD

134

HTML

2529

Figures (1-7)

653

Tables (1-2)

741

Sum=4353

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

343

Download

1206

Sum=1549

Nov 26, 2022 (publication date) through Mar 2, 2026

Times Cited of This Article

Times Cited (4)

Journal Information of This Article

Publication Name

World Journal of Clinical Cases

ISSN

2307-8960

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

- Full Article with Cover (PDF)
- Full Article (XML)

Clinical and Translational Research

World J Clin Cases. Nov 26, 2022; 10(33): 12104-12115
Published online Nov 26, 2022. doi: 10.12998/wjcc.v10.i33.12104

Molecular mechanisms of Baihedihuang decoction as a treatment for breast cancer related anxiety: A network pharmacology and molecular docking study

Zhong-Hui Li, Guo-Hua Yang, Fang Wang

Zhong-Hui Li, Guo-Hua Yang, Fang Wang, Department of Oncology, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing 100102, China

Author contributions: Li ZH wrote the manuscript; Yang GH and Wang F provided key comments and revised the manuscript; all authors approved the final manuscript.

Conflict-of-interest statement: All authors declare that there is no conflict of interest regarding the publication of this paper.

Data sharing statement: Technical appendix, statistical code, and dataset available from the manuscript.

Corresponding author: Fang Wang, MD, Chief Doctor, Department of Oncology, Wangjing Hospital, China Academy of Chinese Medical Sciences, No. 6 Huajiadi Street, Chaoyang District, Beijing 100102, China. wf074500@163.com

Received: July 15, 2022
Peer-review started: July 15, 2022
First decision: August 21, 2022
Revised: September 4, 2022
Accepted: October 12, 2022
Article in press: October 12, 2022
Published online: November 26, 2022
Processing time: 130 Days and 22.9 Hours

Core Tip

Core Tip: Baihedihuang decoction (BD) has significant effects on breast cancer related anxiety; however, its molecular targets in this condition remain unknown. We conducted a network pharmacology and molecular docking study to determine whether BD ingredients target molecules and signaling pathways related to breast cancer related anxiety pathogenesis. The main active ingredients identified include verbascoside, β-sitosterol, stigmasterol, and catalpol. Target genes included CDK2, TP53, HTR2A, and ESR1, which are involved in cell cycle, apoptosis, cell autophagy, blood circulation, and other biological processes. Our results confirm that BD can treat breast cancer related anxiety through multi-component, multi-target, and multi-channel synergy.