Published online Nov 26, 2022. doi: 10.12998/wjcc.v10.i33.12104
Peer-review started: July 15, 2022
First decision: August 21, 2022
Revised: September 4, 2022
Accepted: October 12, 2022
Article in press: October 12, 2022
Published online: November 26, 2022
Processing time: 130 Days and 22.9 Hours
The treatment effect of breast cancer related anxiety is not good and the side effects are obvious. The clinical effect of Baihedihuang decoction is better, but its mechanism is unknown.
To explore the mechanism of Baihedihuang decoction in treating breast cancer related anxiety.
To explore the relationship between drug targets of Baihedihuang decoction and breast cancer related anxiety disorders.
Network pharmacology and molecular docking technology were mainly used in this study.
We screened 16 active ingredients of Baihedihuang decoction for breast cancer related anxiety, with 113 target proteins. Finally, molecular docking was performed with Vina software to validate the key active ingredients in Baihedihuang decoction with the selected key action targets. The molecular docking results showed that verbascoside, β-sitosterol, stigmasterol, and CDK2 could stably bind and interact through amino acid residues SER249, ARG260, PRO228, ALA282, SER276, LYS273, ASN272, etc.
The therapeutic effect of Baihedihuang decoction for breast cancer related anxiety is multi-level, multi-target, and multi-pathway.
The results of this study could serve as a fundamental basis for the further exploration in the in vitro and in vivo experiments for clinical promotions.