Lin WX, Xie YN, Chen YK, Cai JH, Zou J, Zheng JH, Liu YY, Li ZY, Chen YX. Nomogram for predicting overall survival in Chinese triple-negative breast cancer patients after surgery. World J Clin Cases 2022; 10(31): 11338-11348 [PMID: 36387832 DOI: 10.12998/wjcc.v10.i31.11338]
Corresponding Author of This Article
Ye-Xi Chen, MD, Doctor, Department of Thyroid, Breast and Hernia Surgery, The Second Affiliated Hospital of Shantou University Medical College, No. 69 North Dongxia Road, Shantou 515041, China. yxchen3@stu.edu.cn
Research Domain of This Article
Oncology
Article-Type of This Article
Retrospective Study
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Lin WX, Xie YN, Chen YK, Cai JH, Zou J, Zheng JH, Liu YY, Li ZY, Chen YX. Nomogram for predicting overall survival in Chinese triple-negative breast cancer patients after surgery. World J Clin Cases 2022; 10(31): 11338-11348 [PMID: 36387832 DOI: 10.12998/wjcc.v10.i31.11338]
Wei-Xun Lin, Yao-Kun Chen, Jie-Hui Cai, Juan Zou, Jie-Hua Zheng, Yi-Yuan Liu, Zhi-Yang Li, Ye-Xi Chen, Department of Thyroid, Breast and Hernia Surgery, The Second Affiliated Hospital of Shantou University Medical College, Shantou 515041, Guangdong Province, China
Yan-Na Xie, Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Shantou University Medical College, Shantou 515041, Guangdong Province, China
Author contributions: Lin WL, Xie YN, Chen YX, Li ZY, Liu YY, and Cai JH designed the study and conceived the project; Zou J, Zheng JH, Chen YK, and Xie YN performed the experiments and analyzed the data; Lin WX and Xie YN drafted the manuscript; All authors have read and approved the manuscript.
Supported bythe Special Fund Project of Guangdong Science and Technology, No. 210728156901524, and No. 210728156901519; Medical Scientific Research Foundation of Guangdong Province, China, No. A2021432, and No. B2021448; Shantou Medical Science and Technology Planning Project, No. 210521236491457, and No. 210625106490696.
Institutional review board statement: Not applicable, Patient data comes from the SEER*stat version 8.3.5.
Informed consent statement: Not applicable, Patient data comes from the SEER*stat version 8.3.5.
Conflict-of-interest statement: All the authors declare that they have no conflict of interest.
Data sharing statement: No additional data are available.
Corresponding author: Ye-Xi Chen, MD, Doctor, Department of Thyroid, Breast and Hernia Surgery, The Second Affiliated Hospital of Shantou University Medical College, No. 69 North Dongxia Road, Shantou 515041, China. yxchen3@stu.edu.cn
Received: September 12, 2021 Peer-review started: September 12, 2021 First decision: January 10, 2022 Revised: January 25, 2022 Accepted: August 6, 2022 Article in press: August 6, 2022 Published online: November 6, 2022 Processing time: 409 Days and 14.9 Hours
Core Tip
Core tip: This study aimed to construct and validate a nomogram for overall survival (OS) of triple-negative breast cancer (TNBC) patients after surgery. The data from SEER*stat 8.3.5 of selected Chinese surgical patients with TNBC between 2010 and 2015 were used. The multivariate analysis showed that age (P = 0.043), marital status (P = 0.040), tumor localization (P = 0.030), grade (P = 0.035), T classification (P = 0.012), and N classification (P = 0.002) were independent prognostic factors. A risk stratification model was generated. The C-indexes of the nomogram to predict OS were 0.766 and compared to the seventh edition tumor, node, metastasis (TNM) staging system, which was higher (0.766 vs 0.707, P < 0.001). The nomogram provided a clear prognostic superiority over the traditional TNM system.
