Clinical and Translational Research
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Nov 6, 2022; 10(31): 11299-11312
Published online Nov 6, 2022. doi: 10.12998/wjcc.v10.i31.11299
Screening of traditional Chinese medicine monomers as ribonucleotide reductase M2 inhibitors for tumor treatment
Ya-Ya Qin, Song Feng, Xiao-Dong Zhang, Bin Peng
Ya-Ya Qin, Xiao-Dong Zhang, Department of Neurology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, Sichuan Province, China
Song Feng, Bin Peng, School of Basic Medicine, North Sichuan Medical College, Nanchong 637000, Sichuan Province, China
Author contributions: Qin YY wrote the manuscript, designed the study, and acquired data; Feng S acquired, analyzed, and interpreted the data; Zhang XD supervised, reviewed, and edited the manuscript; Peng B designed and coordinated the study, collected funds; all authors approved the final draft.
Supported by Nanchong City School’s Science and Technology Strategic Cooperation, China, No. 20SXQT0304; Research and Development Project Plan of Affiliated Hospital of North Sichuan Medical College, China, No. 2020ZD003.
Institutional review board statement: Not applicable.
Informed consent statement: Not applicable.
Conflict-of-interest statement: All authors declare that they have no conflicts of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Bin Peng, MD, Professor, School of Basic Medicine, North Sichuan Medical College, No. 234 Fujiang Road, Shunqing District, Nanchong 637000, Sichuan Province, China. binpeng01@sina.com
Received: June 23, 2022
Peer-review started: June 23, 2022
First decision: September 5, 2022
Revised: September 14, 2022
Accepted: September 29, 2022
Article in press: September 29, 2022
Published online: November 6, 2022
Processing time: 126 Days and 0.9 Hours
Core Tip

Core Tip: Tumors seriously threaten human life and health. In our work, we found that ribonucleotide reductase M2 (RRM2) is highly expressed in most tumor tissues, and is related to poor prognosis. Seven traditional Chinese medicine monomers with good binding ability to RRM2 were identified, and their binding sites were summarized and analyzed. Those will provide ideas for the development of anti-tumor drugs with RRM2 inhibition in the future.