Chen RH, Li BF, Wen JH, Zhong CL, Ji MM. Clinical and electroencephalogram characteristics and treatment outcomes in children with benign epilepsy and centrotemporal spikes. World J Clin Cases 2021; 9(33): 10116-10125 [PMID: 34904081 DOI: 10.12998/wjcc.v9.i33.10116]
Corresponding Author of This Article
Bing-Fei Li, BMed, Chief Physician, Department of Pediatrics, Ganzhou Maternal and Child Health Hospital, No. 106 Dagong Road, Zhanggong District, Ganzhou 341000, Jiangxi Province, China. jxgzlbf2021@126.com
Research Domain of This Article
Clinical Neurology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Nov 26, 2021; 9(33): 10116-10125 Published online Nov 26, 2021. doi: 10.12998/wjcc.v9.i33.10116
Clinical and electroencephalogram characteristics and treatment outcomes in children with benign epilepsy and centrotemporal spikes
Rui-Hua Chen, Bing-Fei Li, Jian-Hua Wen, Chun-Lan Zhong, Ming-Ming Ji
Rui-Hua Chen, Department of Children’s Neurology, Ganzhou Maternal and Child Health Hospital, Ganzhou 341000, Jiangxi Province, China
Bing-Fei Li, Chun-Lan Zhong, Ming-Ming Ji, Department of Pediatrics, Ganzhou Maternal and Child Health Hospital, Ganzhou 341000, Jiangxi Province, China
Jian-Hua Wen, Department of Pediatrics, Ningdu County People's Hospital, Ganzhou 341000, Jiangxi Province, China
Author contributions: Chen RH and Li BF designed this retrospective study; Chen RH wrote the paper; Chen RH, Li BF, Wen JH, Zhong CL, and Ji MM were responsible for sorting the data.
Institutional review board statement: This study was approved by the Ganzhou Maternal and Child Health Hospital Medical Ethics Committee.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: This is no conflict of interest to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Bing-Fei Li, BMed, Chief Physician, Department of Pediatrics, Ganzhou Maternal and Child Health Hospital, No. 106 Dagong Road, Zhanggong District, Ganzhou 341000, Jiangxi Province, China. jxgzlbf2021@126.com
Received: July 6, 2021 Peer-review started: July 6, 2021 First decision: July 26, 2021 Revised: August 8, 2021 Accepted: August 27, 2021 Article in press: August 27, 2021 Published online: November 26, 2021 Processing time: 139 Days and 1.2 Hours
ARTICLE HIGHLIGHTS
Research background
The primary goal of antiepileptic treatments is to completely control epileptic seizures, while simultaneously considering prevention, control, and improvement of cognitive and behavioral dysfunction is of great significance for improving the patients’ intellectual development and quality of life.
Research motivation
In this study, the clinical and electroencephalograms (EEG) characteristics of children with benign epilepsy and centrotemporal spikes were analyzed, and the children’s treatment and outcomes also discussed.
Research objectives
This study aimed to determine the clinical and EEG characteristics and treatment results of benign epilepsy in spiking children.
Research methods
A total of 106 benign epilepsy children with myocardial spines were included. Differences in clinical data and EGG characteristics between treatment-effective/-ineffective patients were analyzed, and children’s intellectual development before and after treatment evaluated using the Gesell Development Diagnostic Scale.
Research results
EEG showed that the discharge proportion in the awake and sleep periods was 66.04%, and the peak/peak discharge was mainly single-sided, accounting for 81.13%, while the discharge generalization accounted for 31.13%. The discharge index was negatively correlated with fine motor skill and language development, but not with the rest. The discharge index of the responsive group after treatment was significantly lower than that of the unresponsive group.
Research conclusions
The EGG of children with benign epilepsy and centrotemporal spikes has characteristic changes, and therapeutic effects are affected by the age and attack frequency at the time of onset.
Research perspectives
Further research expanding the sample size and extending follow-up time is needed.
