Liu Y, Shuai P, Liu YP, Li DY. Association between Helicobacter pylori infection and food-specific immunoglobulin G in Southwest China. World J Clin Cases 2021; 9(32): 9815-9824 [PMID: 34877320 DOI: 10.12998/wjcc.v9.i32.9815]
Corresponding Author of This Article
Dong-Yu Li, MD, Doctor, Health Management Center, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, No. 32 Section 2, West 1st Ring Road, Qingyang District, Chengdu 611731, Sichuan Province, China. dongyuzhiyin@163.com
Research Domain of This Article
Infectious Diseases
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Nov 16, 2021; 9(32): 9815-9824 Published online Nov 16, 2021. doi: 10.12998/wjcc.v9.i32.9815
Association between Helicobacter pylori infection and food-specific immunoglobulin G in Southwest China
Ying Liu, Ping Shuai, Yu-Ping Liu, Dong-Yu Li
Ying Liu, Ping Shuai, Yu-Ping Liu, Dong-Yu Li, Health Management Center, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu 611731, Sichuan Province, China
Ying Liu, Ping Shuai, Yu-Ping Liu, Dong-Yu Li, Health Management Center, Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu 610072, Sichuan Province, China
Author contributions: Liu Y and Li DY contributed to the conception and design of the work; Liu Y and Shuai P contributed to the acquisition, analysis and interpretation of data for the study; Liu Y contributed to drafting the work; Li DY and Liu YP revised the manuscript; Li DY was accountable for all aspects of the work.
Supported byKey Research and Development Projects of the Ministry of Science and Technology, China, No. 2017YFC0113901.
Institutional review board statement: The study was reviewed and approved by the Ethical Committee of Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital [Approval No. 408(2020)].
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Dong-Yu Li, MD, Doctor, Health Management Center, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, No. 32 Section 2, West 1st Ring Road, Qingyang District, Chengdu 611731, Sichuan Province, China. dongyuzhiyin@163.com
Received: June 27, 2021 Peer-review started: June 27, 2021 First decision: July 14, 2021 Revised: July 19, 2021 Accepted: September 1, 2021 Article in press: September 1, 2021 Published online: November 16, 2021 Processing time: 135 Days and 13.4 Hours
ARTICLE HIGHLIGHTS
Research background
Helicobacter pylori (H. pylori) has been found to be associated with extragastrointestinal diseases, possibly including adverse food reactions (such as food allergy or intolerance). However, there are few studies on H. pylori and food allergy or intolerance, and the results are inconsistent.
Research motivation
Food-specific immunoglobulin (Ig) G has been revealed to be associated with food allergy or intolerance and can be used as a marker to explore the correlation between H. pylori infection and food allergy or intolerance.
Research objectives
To explore the relationship between H. pylori infection and food-specific IgG.
Research methods
H. pylori infection was detected with the 13C urea breath test. Food-specific IgG of eggs, milk and wheat was detected in serum. Subjects were grouped according to H. pylori positivity, and the positive rates of three kinds of food-specific IgG were compared between the two groups. Multivariable logistic regression analysis was performed to identify the association between H. pylori infection and food-specific IgG.
Research results
In the H. pylori-positive groups, the positive rates of food-specific IgG of eggs, milk and wheat were all lower than those in the H. pylori-negative groups. Multivariate logistic regression analysis showed that H. pylori infection was negatively correlated with the food-specific IgG-positive rates of eggs, milk, and wheat.
Research conclusions
H. pylori infection was negatively correlated with the food-specific IgG of eggs, milk and wheat in Southwest China.
Research perspectives
Our study might reflect only a negative association between H. pylori infection and food-specific IgG rather than causality. Establishing relevant animal models and exploring the underlying mechanism based on immunity or a well-designed clinical intervention study may help to verify our findings. Moreover, finding additional similar “protective” effects in asymptomatic patients with H. pylori infection may help us reassess the role of H. pylori in the body and provide advisable suggestions for medical decisions.
