Association between Helicobacter pylori infection and food-specific immunoglobulin G in Southwest China

Abstract

BACKGROUND

Helicobacter pylori (H. pylori) has been found to be associated with extragastrointestinal diseases, possibly including adverse food reactions (such as food allergy or intolerance). However, there are few studies on H. pylori and food allergy or intolerance, and the results are inconsistent. Food-specific immunoglobulin (Ig) G has been revealed to be associated with food allergy or intolerance and can be used as a marker to explore the correlation between H. pylori infection and food allergy or intolerance.

AIM

To explore the relationship between H. pylori infection and food-specific IgG

METHODS

We retrospectively analyzed the physical examination data of 21822 subjects from February 2014 to December 2018 in this study. H. pylori infection was detected using the ¹³C urea breath test. Food-specific IgG of eggs, milk and wheat in serum was assessed. Subjects were grouped according to H. pylori positivity, and the positive rates of three kinds of food-specific IgG were compared between the two groups. Multivariable logistic regression analysis was performed to elucidate the association between H. pylori infection and food-specific IgG.

RESULTS

The total infection rate of H. pylori was 39.3%, and the total food-specific IgG-positive rates of eggs, milk and wheat were 25.2%, 9.0% and 4.9%, respectively. The infection rate of H. pylori was higher in males than in females, while the positive rates of food-specific IgG were lower in males than in females. The positive rates of food-specific IgG decreased with age in both males and females. In the H. pylori-positive groups, the positive rates of food-specific IgG of eggs, milk and wheat were all lower than those in the H. pylori-negative groups. Multivariate logistic regression analysis revealed that H. pylori infection was negatively correlated with the food-specific IgG-positive rates of eggs, milk and wheat (odds ratio value of eggs 0.844-0.873, milk 0.741-0.751 and wheat 0.755-0.788, in different models).

CONCLUSION

H. pylori infection was found to be negatively associated with the food-specific IgG of eggs, milk and wheat in Southwest China.

Keywords: Food-specific IgG; Helicobacter pylori; Adverse food reaction; Food allergy; Food intolerance; Humoral immunity

Core Tip: This is a retrospective study to evaluate the association of Helicobacter pylori (H. pylori) infection and food-specific immunoglobulin G. We analyzed the data of 21822 subjects who underwent H. pylori infection assessment by the urea breath test and testing for food-specific immunoglobulin G of eggs, milk and wheat. The key finding was that H. pylori infection was associated with lower positivity for food-specific immunoglobulin G. If the negative correlation could be further confirmed and the mechanism could be clarified, it would provide some advisable suggestions for medical decisions regarding asymptomatic H. pylori infection.