Zhu YC, Sun YX, Shen XY, Jiang Y, Liu JY. Effect of intrauterine perfusion of granular leukocyte-colony stimulating factor on the outcome of frozen embryo transfer. World J Clin Cases 2021; 9(30): 9038-9049 [PMID: 34786386 DOI: 10.12998/wjcc.v9.i30.9038]
Corresponding Author of This Article
Jing-Yu Liu, MM, MS, Doctor, Reproductive Medicine Center, The Affiliated Drum Tower Hospital of Nanjing University Medical School, No. 321 Zhongshan Road, Nanjing, Nanjing 210008, China. lianjing1216@126.com
Research Domain of This Article
Obstetrics & Gynecology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Oct 26, 2021; 9(30): 9038-9049 Published online Oct 26, 2021. doi: 10.12998/wjcc.v9.i30.9038
Effect of intrauterine perfusion of granular leukocyte-colony stimulating factor on the outcome of frozen embryo transfer
Ying-Chun Zhu, Yan-Xin Sun, Xiao-Yue Shen, Yue Jiang, Jing-Yu Liu
Ying-Chun Zhu, Yan-Xin Sun, Xiao-Yue Shen, Yue Jiang, Jing-Yu Liu, Reproductive Medicine Center, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, Jiangsu Province, China
Author contributions: Jiang Y and Liu JY contributed to the project development and manuscript editing; Shen XY and Zhu YC contributed to the experiments; Shen XY and Zhu YC contributed to the data collection and manuscript writing; Sun YX and Zhu YC contributed to the data management and data analysis.
Supported byChinese Medical Association, No. 17020450714; and Medical Science and Technology Development Foundation, Nanjing Department of Health, No. YKK18090.
Institutional review board statement: This study was approved by the ethics committee of the Affiliated Drum Tower Hospital of Nanjing University Medical School (Approval No. 2020-064-01).
Informed consent statement: Patients were not required to provide informed consent because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: All authors declare that there are no any conflicts of interest.
Data sharing statement: The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jing-Yu Liu, MM, MS, Doctor, Reproductive Medicine Center, The Affiliated Drum Tower Hospital of Nanjing University Medical School, No. 321 Zhongshan Road, Nanjing, Nanjing 210008, China. lianjing1216@126.com
Received: March 12, 2021 Peer-review started: March 12, 2021 First decision: July 26, 2021 Revised: August 4, 2021 Accepted: September 14, 2021 Article in press: September 14, 2021 Published online: October 26, 2021 Processing time: 222 Days and 23.9 Hours
ARTICLE HIGHLIGHTS
Research background
Endometrial thickness is one of the most important factors predicting the outcome of pregnancy. Women with a thin endometrium have difficulty obtaining good pregnancy outcome. Treatment of thin endometrium with granular leukocyte-colony stimulating factor (G-CSF) remains controversial.
Research motivation
G-CSF administration for the treatment of thin endometrium remains controversial.
Research objectives
This study aimed to investigate the effect of G-CSF on the outcome of frozen embryo transfer in patients with thin endometrium.
Research methods
A retrospective propensity score matching (PSM) study was performed to assess patients administered frozen embryo transfer at the Reproductive Medicine Center of the Affiliated Drum Tower Hospital of Nanjing University Medical School, in 2012-2018. The patients were divided into G-CSF intrauterine perfusion (G-CSF) and non-G-CSF groups, and clinical pregnancy, implantation, ectopic pregnancy, and early abortion rates between the two groups were compared.
Research results
After PSM by age and blastula/cleavage stage embryo ratio, 244 cycles were included (122 cases each in the G-CSF and non-G-CSF groups). The clinical pregnancy (50.82 % vs 48.36%; P = 0.701) and embryo implantation (37.38% vs 34.11%; P = 0.480) remained similar in both groups.
Research conclusions
This study suggested that G-CSF intrauterine infusion does not improve the clinical outcome of frozen embryo transfer in patients with thin endometrium.
Research perspectives
It provides some ideas for the G-CSF treatment of patients with thin endometrium.However, large well-designed multi-center studies are warranted to comprehensively determine the effects of G-CSF on pregnancy outcome in patients with thin endometrium.
