Published online Aug 6, 2021. doi: 10.12998/wjcc.v9.i22.6278
Peer-review started: April 11, 2021
First decision: April 23, 2021
Revised: May 6, 2021
Accepted: May 19, 2021
Article in press: May 19, 2021
Published online: August 6, 2021
Processing time: 107 Days and 18.3 Hours
The currently recommended treatment modality for bile duct cyst (BDC) is operation due to the high incidence of bile duct malignancy. However, few studies have been conducted on the risk factors for preoperative carcinogenesis of BDC patients.
To find out the patient features that are indications for surgery in BDC and provide better treatment recommendation.
To analyze the risk factors associated with preoperative carcinogenesis in BDC patients.
This retrospective study included patients with BDC treated at our hospital between January 2012 and December 2018. A database containing demographic characteristics, symptoms, laboratory tests, operation details, pathology information, and prognoses was constructed. The characteristics of BDC with dysplasia/carcinoma were compared with benign cysts. Univariate and multivariate analyses were used to analyze the risk factors for preoperative carcinogenesis.
A total of 109 patients with BDC were included. Ten patients had preoperative dysplasia or adenocarcinoma. Univariate analysis showed that gallbladder wall thickness > 0.3 cm, cyst transverse diameter > 3 cm, and Todani type IV were associated with preoperative carcinogenesis. Multivariate logistic regression analysis showed that gallbladder wall thickness > 0.3 cm and Todani type IV were independently associated with preoperative carcinogenesis. The follow-up information of ten patients with dysplasia/carcinoma was presented.
BDC is a premalignant condition. Gallbladder wall thickness > 0.3 cm and Todani type IV are independent risk factors for preoperative carcinogenesis.
The two risk factors are useful for deciding on the appropriate treatment strategy, especially in asymptomatic patients.