Impact of simethicone on bowel cleansing during colonoscopy in Chinese patients

doi:10.12998/wjcc.v9.i10.2238

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Apr 6, 2021 (publication date) through Feb 26, 2026

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World Journal of Clinical Cases

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World J Clin Cases. Apr 6, 2021; 9(10): 2238-2246
Published online Apr 6, 2021. doi: 10.12998/wjcc.v9.i10.2238

Impact of simethicone on bowel cleansing during colonoscopy in Chinese patients

Hu Zhang, Jing Liu, Song-Lin Ma, Man-Lin Huang, Yan Fan, Min Song, Jing Yang, Xiao-Xia Zhang, Qi-Long Song, Jing Gong, Ping-Xiao Huang, Heng Zhang

Hu Zhang, Jing Liu, Song-Lin Ma, Man-Lin Huang, Yan Fan, Min Song, Jing Yang, Xiao-Xia Zhang, Qi-Long Song, Jing Gong, Ping-Xiao Huang, Heng Zhang, Department of Gastroenterology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430014, Hubei Province, China

Hu Zhang, Department of Gastroenterology, The Eighth Hospital of Wuhan, Wuhan 430014, Hubei Province, China

Author contributions: Zhang H designed this study and critically revised the manuscript; Zhang H, Liu J, and Ma SL were responsible for data acquisition and extraction; Zhang H drafted the manuscript, analyzed the data, and interpreted the results; Huang ML, Fan Y, Song M, Zhang XX, Song QL, Gong J, Yang J, and Huang PX were involved in editing the manuscript; all authors read and approved the final manuscript to be published.

Supported by Natural Science Foundation of Wuhan, No. WX18Y04.

Institutional review board statement: The study was approved by the medical ethics committee of The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology Institutional (Approval No. 2019-9).

Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.

Conflict-of-interest statement: All of the authors declare that they have no conflicts of interest regarding this paper.

Data sharing statement: Participants gave informed consent for data sharing.

STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.

Corresponding author: Heng Zhang, MA, MD, Chief Doctor, Professor, Department of Gastroenterology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, No. 26 Shengli Road, Jiang'an District, Wuhan 430014, Hubei Province, China. 497697662@qq.com

Received: December 17, 2020
Peer-review started: December 17, 2020
First decision: January 6, 2021
Revised: January 13, 2021
Accepted: January 26, 2021
Article in press: January 26, 2021
Published online: April 6, 2021
Processing time: 102 Days and 20.4 Hours

ARTICLE HIGHLIGHTS

Research background

The incidence and mortality of colorectal cancer (CRC) have been rapidly increasing in China over the last decade.

Research motivation

A high-quality bowel preparation is a key determinant of the efficacy of colonoscopy to reduce the incidence of CRC, but an ideal bowel cleansing regimen for screening CRC has yet to be determined in a Chinese population.

Research objectives

Explore an ideal bowel cleansing regimen for a colonoscopy.

Research methods

Bowel-cleansing efficacy was evaluated by endoscopists using the Boston bowel preparation scale (BBPS) and the bubbles score.

Research results

The BBPS score of the right-side colon was significantly higher, and significantly more proximal adenomas were detected in the 3 L polyethylene glycol (PEG) plus simethicone (3-PS) group. More patients in the 3-PS group expressed willingness to repeat the bowel preparation.

Research conclusions

Three-liter PEG shows satisfactory bowel cleansing and addition of simethicone with better bubble elimination and enhanced patient acceptance offers an excellent potential impact on the detection of proximal adenomas in Chinese populations.

Research perspectives

Three-liter plus simethicone may be a reliable bowel preparation for screening and surveillance colonoscopy.