Simsek C, Uner M, Ozkara F, Akman O, Akyol A, Kav T, Sokmensuer C, Gedikoglu G. Comprehensive clinicopathologic characteristics of intraabdominal neurogenic tumors: Single institution experience. World J Clin Cases 2021; 9(10): 2218-2227 [PMID: 33869597 DOI: 10.12998/wjcc.v9.i10.2218]
Corresponding Author of This Article
Cem Simsek, MD, Academic Fellow, Department of Gastroenterology, Hacettepe University, Sihhiye, Ankara 06230, Turkey. cemgsimsek@gmail.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Cem Simsek, Taylan Kav, Department of Gastroenterology, Hacettepe University, Ankara 06230, Turkey
Meral Uner, Aytekin Akyol, Cenk Sokmensuer, Gokhan Gedikoglu, Department of Pathology, Hacettepe University, Ankara 06230, Turkey
Feride Ozkara, Department of Internal Medicine, Hacettepe University, Ankara 06230, Turkey
Orkun Akman, Department of Pathology, Yozgat City Hospital, Yozgat 66100, Turkey
Author contributions: Simsek C, Ozkara F, Bugdayci Uner M and Gedikoglu G gathered patient information, analyzed histology, collected data, performed analysis, constructed manuscript; Kav T, Akyol A, Akman O and Sokmensuer C contributed to conception of the study and manuscript preparation.
Institutional review board statement: This study was reviewed and approved by the Hacettepe University Institutional Review Board (Approval No. GO 20-1112).
Informed consent statement: Due to the retrospective nature of the study, the need for informed consent was waived by the Hacettepe University Institutional Review Board.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest, either real or perceived, in relation to this study.
Data sharing statement: Anonymized data are available and can be shared upon reasonable request.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Cem Simsek, MD, Academic Fellow, Department of Gastroenterology, Hacettepe University, Sihhiye, Ankara 06230, Turkey. cemgsimsek@gmail.com
Received: December 21, 2020 Peer-review started: December 21, 2020 First decision: December 31, 2020 Revised: January 12, 2021 Accepted: February 11, 2021 Article in press: February 11, 2021 Published online: April 6, 2021 Processing time: 98 Days and 14.5 Hours
ARTICLE HIGHLIGHTS
Research background
Abdominal neurogenic tumors constitute an extremely rare yet important group of intraabdominal soft tissue lesions.
Research motivation
The current knowledge regarding abdominal neurogenic tumors is limited. A more detailed understanding of their clinical and pathological characteristics will benefit diagnosis as well as management of these tumors and their disease manifestations.
Research objectives
We aimed to delineate the comprehensive clinical, radiologic and histopathological characteristics of intraabdominal neurogenic tumors.
Research methods
We reviewed a nationwide referral center’s 15 years’ worth of biobank data, collecting clinical, radiologic and clinical variables of all patients during that period. In addition, we obtained the archived paraffin-embedded specimens for each of the 19 cases identified and re-evaluated the histopathologic and immunohistochemical features.
Research results
Nineteen cases of tumors were identified from our database for the 15-year period. The most common lesion was schwannoma (n = 12), followed by diffuse submucosal neurofibromatosis, ganglioneuromas, and malignant peripheral sheath nerve tumors (n = 2 each), and mucosal Schwann cell hamartoma (n = 1).
Research conclusions
Intraabdominal neurogenic tumors have excellent clinical outcome. However, there are nuances in their radiologic, endoscopic and histologic diagnoses.
Research perspectives
Multi-institutional studies with larger study populations are merited.
