Wang F, Gao SG, Xue Q, Tan FW, Gao YS, Mao YS, Wang DL, Zhao J, Li Y, Yu XY, Cheng H, Zhao CG, Mu JW. Log odds of positive lymph nodes is a better prognostic factor for oesophageal signet ring cell carcinoma than N stage. World J Clin Cases 2021; 9(1): 24-35 [PMID: 33511169 DOI: 10.12998/wjcc.v9.i1.24]
Corresponding Author of This Article
Ju-Wei Mu, MD, Doctor, Professor, Surgeon, Surgical Oncologist, Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, National Cancer Center, No. 17 Panjiayuan Nanli, Chaoyang District, Beijing 100021, China. mujuwei@cicams.ac.cn
Research Domain of This Article
Medicine, Research & Experimental
Article-Type of This Article
Retrospective Cohort Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Jan 6, 2021; 9(1): 24-35 Published online Jan 6, 2021. doi: 10.12998/wjcc.v9.i1.24
Log odds of positive lymph nodes is a better prognostic factor for oesophageal signet ring cell carcinoma than N stage
Feng Wang, Shu-Geng Gao, Qi Xue, Feng-Wei Tan, Yu-Shun Gao, You-Sheng Mao, Da-Li Wang, Jun Zhao, Yin Li, Xiang-Yang Yu, Hong Cheng, Chen-Guang Zhao, Ju-Wei Mu
Feng Wang, Shu-Geng Gao, Qi Xue, Feng-Wei Tan, Yu-Shun Gao, You-Sheng Mao, Da-Li Wang, Jun Zhao, Yin Li, Xiang-Yang Yu, Hong Cheng, Chen-Guang Zhao, Ju-Wei Mu, Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
Author contributions: Wang F drafted the manuscript, got data from the SEER database, and assisted with data analysis; Gao SG participated in design and oversight of the study; Xue Q and Tan FW participated in design of the study and were involved in data collection; Gao YS, Mao YS, Wang DL, Zhao J, and Li Y participated in study design; Yu XT, Cheng H, and Zhao CG were involved in data collection and statistical analysis; all authors read and approved the final manuscript.
Supported bythe Capital Health Development Research Project, No. 2014-1-4021.
Institutional review board statement: The study was reviewed and approved for publication by National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Institutional Review Board.
Informed consent statement: As the study cohort is based on a publicly available database without identifying patient information, informed consent was not needed. Informed consent was provided by all cases in the validation cohort.
Conflict-of-interest statement: All the authors have no conflict of interest related to the article.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ju-Wei Mu, MD, Doctor, Professor, Surgeon, Surgical Oncologist, Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, National Cancer Center, No. 17 Panjiayuan Nanli, Chaoyang District, Beijing 100021, China. mujuwei@cicams.ac.cn
Received: June 27, 2020 Peer-review started: June 27, 2020 First decision: September 30, 2020 Revised: October 9, 2020 Accepted: November 2, 2020 Article in press: November 2, 2020 Published online: January 6, 2021 Processing time: 188 Days and 9.3 Hours
ARTICLE HIGHLIGHTS
Research background
Oesophageal signet ring cell carcinoma is a rare type of cancer, and log odds of positive lymph nodes (LODDS) may be a better prognostic factor for it.
Research motivation
To investigate the predictive value of LODDS for signet ring cell carcinoma of the oesophagus.
Research objectives
To explore whether LODDS is a better prognostic factor than N stage for oesophageal signet ring cell carcinoma.
Research methods
The prognostic values of LODDS and N stage for oesophageal signet ring cell carcinoma were evaluated by univariate and multivariate analyses. The Akaike information criterion and Harrell’s C-index were used to compare the predictive value of the model. External validation was performed to further confirm the conclusion.
Research results
The multivariate Cox regression model showed that LODDS was a significant independent prognostic factor for oesophageal signet ring carcinoma patients. LODDS has better predictive value than N stage. The results of external validation were consistent with those in the study cohort.
Research conclusions
LODDS is a superior prognostic factor for patients with oesophageal signet ring cell carcinoma after oesophagectomy than N stage.
Research perspectives
In the future, it is expected that there will be more studies on oesophageal signet ring cell cancer, and the treatment and diagnosis of this cancer will be continuously improved.
