Artificial dermis combined with skin grafting for the treatment of hand skin and soft tissue defects and exposure of bone and tendon

doi:10.12998/wjcc.v11.i33.8003

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World Journal of Clinical Cases

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Cases. Nov 26, 2023; 11(33): 8003-8012
Published online Nov 26, 2023. doi: 10.12998/wjcc.v11.i33.8003

Artificial dermis combined with skin grafting for the treatment of hand skin and soft tissue defects and exposure of bone and tendon

Wei Wang, Dong-Sheng Chen, Zhao-Di Guo, Dan Yu, Qin Cao, Xiao-Wei Zhu

Wei Wang, Dong-Sheng Chen, Dan Yu, Xiao-Wei Zhu, Department of Operating Room, The First People Hospital of Jiangxia District, Wuhan 430200, Hubei Province, China

Zhao-Di Guo, Qin Cao, Department of Hand Surgery, The First People Hospital of Jiangxia District, Wuhan 430200, Hubei Province, China

Co-first authors: Wei Wang and Dong-Sheng Chen.

Author contributions: Wang W and Chen DS designed the research; Wang W, Chen DS, Guo ZD, Cao Q, and Yu D performed the research; Zhu XW contributed new reagents/analytic tools; Zhu XW, Guo ZD, Cao Q, and Yu D analyzed the data; Wang W and Chen DS wrote the paper; All authors were involved in the critical review of the results and have contributed to, read, and approved the final manuscript. Wang W and Chen DS contributed equally to this work as co-first authors. The reasons for designating Wang W and Chen DS as co-first authors are threefold. First, the research was performed as a collaborative effort, and the designation of co-corresponding authorship accurately reflects the distribution of responsibilities and burdens associated with the time and effort required to complete the study and the resultant paper. This also ensures effective communication and management of post-submission matters, ultimately enhancing the paper's quality and reliability; Second, the overall research team encompassed authors with a variety of expertise and skills from different fields, and the designation of co-first authors best reflects this diversity. This also promotes the most comprehensive and in-depth examination of the research topic, ultimately enriching readers' understanding by offering various expert perspectives; Third, Wang W and Chen DS contributed efforts of equal substance throughout the research process. The choice of these researchers as co-first authors acknowledges and respects this equal contribution, while recognizing the spirit of teamwork and collaboration of this study. In summary, we believe that designating Wang W and Chen DS as co-first authors is fitting for our manuscript as it accurately reflects our team's collaborative spirit, equal contributions, and diversity.

Supported by Clinical Study of Artificial Dermis Combined with Skin Flap Replacement Flap in Limb Wound Repair, No. WX21C27.

Institutional review board statement: This study protocol was approved by The First People’s Hospital of Jiangxia District, and all the families have voluntarily participated in the study and have signed informed consent forms.

Informed consent statement: All study participants or their legal guardian provided informed written consent prior to study enrolment.

Conflict-of-interest statement: All authors declare no conflicts of interest related to this study.

Data sharing statement: Data generated from this investigation are available upon reasonable quest from the corresponding author.

Corresponding author: Xiao-Wei Zhu, MD, Chief Physician, Department of Operating Room, The First People Hospital of Jiangxia District, No. 1 Cultural Avenue, Jiangxia District, Wuhan 430200, Hubei Province, China. xiaoweizhu0818@163.com

Received: September 25, 2023
Peer-review started: September 25, 2023
First decision: October 17, 2023
Revised: October 25, 2023
Accepted: October 30, 2023
Article in press: October 30, 2023
Published online: November 26, 2023
Processing time: 60 Days and 1.8 Hours

ARTICLE HIGHLIGHTS

Research background

When paired with autologous skin transplantation, double layer artificial dermis can promote functional recovery of hands and feet, limit damage to the skin donor area, improve the appearance of the healed wound surface, speed up the healing process, and lower the chance of scar formation and recurrence.

Research motivation

Treatment of chronic and refractory skin and soft tissue defects of the fingers with exposed bones and tendons.

Research objectives

To explore the clinical effect of double layer artificial dermis combined with autologous skin graft in repairing chronic refractory skin and soft tissue defects of the fingers with exposed bone and tendon.

Research methods

Sixty-eight chronic refractory patients with finger skin and soft tissue defects accompanied by bone and tendon exposure admitted to our hospital were selected and divided into the observation group (double layer artificial dermis combined with autologous skin grafting) and the control group (pedicle skin flap transplantation). The treatment status of the two groups of patients was compared, as well as the survival rate, scar formation, recovery, and patient satisfaction with skin grafts/flaps at 6 mo after surgery.

Research results

Recovery, postoperative infection, treatment, and patient satisfaction were better in the observation group than in the control group. Skin sensation recovery and skin graft/flap survival rate did not significantly differ between the control and observation groups.

Research conclusions

The combination of artificial dermis and autologous skin graft has a satisfactory therapeutic effect on hand tendon exposure wounds.

Research perspectives

The combination of artificial dermis and autologous skin grafting can be an effective method for treating hand tendon exposed wounds.