Published online Sep 6, 2022. doi: 10.12998/wjcc.v10.i25.8863
Peer-review started: April 19, 2022
First decision: May 11, 2022
Revised: May 22, 2022
Accepted: July 29, 2022
Article in press: July 29, 2022
Published online: September 6, 2022
Processing time: 128 Days and 23.5 Hours
Patients with prostate cancer (PCa) were divided into low-risk, medium-risk, and high-risk groups. The risk level was associated with 10-year disease-free survival after radical prostatectomy. The 10-year disease-free survival rates of the low-risk, medium-risk, and high-risk groups were 83%, 46%, and 29%, respectively.
Predicting the prognosis in advance according to the degree of risk can provide a basis for individualized treatment options and postoperative adjuvant treatment measures for PCa patients, especially for high/extremely high-risk patients.
Prognostic nutritional index (PNI) is considered to have predictive significance in the prognosis of lung cancer, melanoma, and esophageal cancer. PNI is also associated with the prognosis of PCa.
Patients with PCa were divided into a high PNI group and low PNI group based on the PNI threshold. The progression-free survival was compared between the two groups. Meanwhile, the influencing factors of biological recurrence were analyzed.
The progression-free survival of patients in the low PNI group within 5 years was shorter, and the low PNI and positive incisal margin status were independent predictors of biological recurrence in patients with high/extremely high-risk PCa.
PNI value has predictive significance on the prognosis of patients with high/extremely high-risk PCa.
Calculating the Youden index was used to determine the optimal critical value of PNI. The progression-free survival of low PNI group and high PNI group were compared by Kaplan-Meier survival analysis. The influencing factors of biological recurrence was analyzed by Cox proportional hazards regression model.