Published online Apr 16, 2022. doi: 10.12998/wjcc.v10.i11.3449
Peer-review started: November 10, 2021
First decision: January 11, 2022
Revised: January 25, 2022
Accepted: February 23, 2022
Article in press: February 23, 2022
Published online: April 16, 2022
Processing time: 149 Days and 6.5 Hours
Chronic obstructive pulmonary disease (COPD) is a common public health issue that has been linked to cognitive dysfunction. No clear evidence is available for the relationship between COPD and mild cognitive impairment (MCI) and dementia risk.
To our knowledge, there has only been one published meta-analysis with limited number studies investigating the statistical association of COPD with cognition dysfunction.
The current meta-analysis was performed to investigate the relationship between COPD and MCI and dementia risk.
A comprehensive search was performed using PubMed, Embase, Google Scholar, and Cochrane Library online databases for articles published prior to March 31, 2021.
Twenty-seven studies met all the inclusion criteria. Meta-analysis yielded a strong association between COPD and an increased risk of MCI incidence. It also revealed a borderline trend for an increased dementia risk in COPD patients. A significant lower MMSE score in COPD patients was noted.
Our findings revealed an elevated risk for the occurrence of MCI and dementia in COPD patients. Proper clinical management and attention are required to prevent and control MCI and dementia incidence in COPD patients.
Further large prospective observational studies are needed to strengthen the evidence on this important subject.