Case Report
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Nov 16, 2021; 9(32): 9889-9895
Published online Nov 16, 2021. doi: 10.12998/wjcc.v9.i32.9889
Synchronous multiple primary malignancies of the esophagus, stomach, and jejunum: A case report
Yan Li, Lian-Song Ye, Bing Hu
Yan Li, Lian-Song Ye, Bing Hu, Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Author contributions: Li Y reviewed the literature and drafted the article; Ye LS provided critical revision to the manuscript; Hu B conceived the article; and all authors issued final approval for the version to be submitted.
Informed consent statement: Informed written consent was obtained from the patient’s daughter for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Bing Hu, MD, Professor, Department of Gastroenterology, West China Hospital, Sichuan University, No. 37 Guoxue Alley, Wuhou District, Chengdu 610041, Sichuan Province, China. hubingnj@163.com
Received: April 19, 2021
Peer-review started: April 19, 2021
First decision: June 23, 2021
Revised: June 26, 2021
Accepted: September 8, 2021
Article in press: September 8, 2021
Published online: November 16, 2021
Processing time: 204 Days and 11.3 Hours
Abstract
BACKGROUND

Treatment of synchronous multiple primary malignancies is quite often very challenging. Herein, we report on a rare case of synchronous multiple primary malignancies in the esophagus, stomach, and jejunum.

CASE SUMMARY

A 50-year-old man who was a heavy drinker and smoker with a poor diet, and had a family history of cancer sought treatment due to dysphagia lasting for 4 mo. He was finally diagnosed with lower esophageal squamous cell carcinoma (pT3N2M0, G2, stage IIIB), gastric angular adenocarcinoma (pT3N2M0, G2-G3, stage IIIA) with greater omental lymph node metastasis, and jejunal stromal tumor (high risk). The high-risk jejunal stromal tumor was found during surgery. In spite of radical resection and adjuvant chemotherapy, lymph node metastasis occurred 21 mo later. The patient responded poorly to additional chemotherapy and refused further examination and therapy. He died of widespread metastases 33 mo after surgery.

CONCLUSION

This case indicates a poor prognosis of synchronous multiple advanced primary malignancies and the importance of comprehensive assessment in the population at high risk for cancer.

Keywords: Multiple primary malignancies; Gastrointestinal tract; Diagnosis; Treatment; Case report

Core Tip: This article presents a case with synchronous multiple primary malignancies, including esophageal squamous cell carcinoma, gastric adenocarcinoma, and jejunal stromal tumor. This patient had many cancer-related risk factors like heavy drinking, smoking, and family history. The high-risk jejunal stromal tumor was found during operation. Despite radical surgery and adjuvant chemotherapy, the patient died of widespread metastases 33 mo later. This case suggests a poor prognosis of synchronous multiple advanced primary malignancies and the importance of comprehensive assessment for high-risk populations.