Published online Nov 16, 2021. doi: 10.12998/wjcc.v9.i32.9889
Peer-review started: April 19, 2021
First decision: June 23, 2021
Revised: June 26, 2021
Accepted: September 8, 2021
Article in press: September 8, 2021
Published online: November 16, 2021
Processing time: 204 Days and 11.3 Hours
Treatment of synchronous multiple primary malignancies is quite often very challenging. Herein, we report on a rare case of synchronous multiple primary malignancies in the esophagus, stomach, and jejunum.
A 50-year-old man who was a heavy drinker and smoker with a poor diet, and had a family history of cancer sought treatment due to dysphagia lasting for 4 mo. He was finally diagnosed with lower esophageal squamous cell carcinoma (pT3N2M0, G2, stage IIIB), gastric angular adenocarcinoma (pT3N2M0, G2-G3, stage IIIA) with greater omental lymph node metastasis, and jejunal stromal tumor (high risk). The high-risk jejunal stromal tumor was found during surgery. In spite of radical resection and adjuvant chemotherapy, lymph node metastasis occurred 21 mo later. The patient responded poorly to additional chemotherapy and refused further examination and therapy. He died of widespread metastases 33 mo after surgery.
This case indicates a poor prognosis of synchronous multiple advanced primary malignancies and the importance of comprehensive assessment in the population at high risk for cancer.
Core Tip: This article presents a case with synchronous multiple primary malignancies, including esophageal squamous cell carcinoma, gastric adenocarcinoma, and jejunal stromal tumor. This patient had many cancer-related risk factors like heavy drinking, smoking, and family history. The high-risk jejunal stromal tumor was found during operation. Despite radical surgery and adjuvant chemotherapy, the patient died of widespread metastases 33 mo later. This case suggests a poor prognosis of synchronous multiple advanced primary malignancies and the importance of comprehensive assess