Case Report
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Oct 16, 2021; 9(29): 8782-8788
Published online Oct 16, 2021. doi: 10.12998/wjcc.v9.i29.8782
Samonella typhi infection-related appendicitis: A case report
Bo-Hao Zheng, Wei-Ming Hao, Hung-Chen Lin, Guo-Guo Shang, Han Liu, Xiao-Jian Ni
Bo-Hao Zheng, Han Liu, Xiao-Jian Ni, Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Wei-Ming Hao, Hung-Chen Lin, Shanghai Medical College, Fudan University, Shanghai 200032, China
Guo-Guo Shang, Department of Pathology, Zhongshan Hospital, Shanghai 200032, China
Author contributions: Liu H and Ni XJ designed the case report; Zheng BH, Hao WM, and Lin HC analyzed and interpreted the patient data, and wrote the manuscript; Shang GG took the pathological examination; Zheng BH, Hao WM, Liu H, and Ni XJ participated in patient management; all authors read and approved the final manuscript.
Supported by National Natural Science Foundation of China, No. 81702586.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest to report.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed following the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiao-Jian Ni, MD, PhD, Doctor, Surgeon, Department of General Surgery, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Shanghai 200032, China. nixiaojian13154@126.com
Received: June 7, 2021
Peer-review started: June 7, 2021
First decision: June 25, 2021
Revised: July 5, 2021
Accepted: August 2, 2021
Article in press: August 2, 2021
Published online: October 16, 2021
Processing time: 130 Days and 2.2 Hours
Abstract
BACKGROUND

Acute appendicitis is one of the most common acute abdominal emergencies around the world, which is always associated with infection. Infection with Salmonella typhi, an enteric pathogen, is a rare cause of acute appendicitis. We here report a patient with acute appendicitis associated with Samonella typhi infection, accompanied with spleen and kidney infarction, providing a rare example for a common surgical emergency.

CASE SUMMARY

A 25-year-old Pakistani man presented to the hospital with a 3-d history of fevers, vomiting, and abdominal pain. Computed tomography (CT) revealed a thickened intestinal wall of the ileocecal junction with multiple enlarged lymph nodes nearby. He was diagnosed with acute appendicitis and received laparoscopic appendectomy, which showed mild inflammation of the appendix. After the surgery, the patient presented again with a high fever (> 39 °C) and diarrhea. A CT angiography scan indicated spleen and kidney infarction. According to the blood culture, the diagnosis was finally clear to be Samonella typhi infection. The pyrexia and enteric symptoms were relieved after the application of intravenous levofloxacin.

CONCLUSION

This case, characterized by the combination of Salmonella typhi infection, acute appendicitis, and renal and splenic infraction, serves as a rare example for a common surgical emergency.

Keywords: Acute appendicitis; Samonella typhi infection; Enteric pathogen; Laparoscopic appendectomy; Case report

Core Tip: Acute appendicitis is one of the most common acute abdominal emergencies around the world, which is always associated with infection. Infection with Salmonella typhi, an enteric pathogen, is a rare cause of acute appendicitis. We here report a patient with acute appendicitis associated with Samonella typhi infection, accompanied by spleen and kidney infarction, providing a rare example for a common surgical emergency. This case might remind emergency doctors that the etiology of appendicitis needs to be clarified to give appropriate treatment to patients with appendicitis.