Zhang YS, Li XJ, Zhang YH, Hu TC, Chen WZ, Pan X, Chai HY, Wang X, Yang YL. Carbon ion radiotherapy for bladder cancer: A case report. World J Clin Cases 2021; 9(26): 7833-7839 [PMID: 34621834 DOI: 10.12998/wjcc.v9.i26.7833]
Corresponding Author of This Article
Yan-Shan Zhang, PhD, Chief Doctor, Heavy Ion Center, Wuwei Cancer Hospital, No. 31 Sanitary Lane, Haizang Road, Wuwei 733000, Gansu Province, China. 13830510999@163.com
Research Domain of This Article
Radiology, Nuclear Medicine & Medical Imaging
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Yan-Shan Zhang, Xiao-Jun Li, Yi-He Zhang, Ting-Chao Hu, Wei-Zuo Chen, Xin Pan, Hong-Yu Chai, Xin Wang, Yu-Ling Yang, Heavy Ion Center, Wuwei Cancer Hospital, Wuwei 733000, Gansu Province, China
Author contributions: Zhang YS and Li XJ equally contributed to this article and should be regarded as co-first authors; Zhang YS, Li XJ, Zhang YH, and Hu TC designed the study; Chen WZ, Pan X, and Chai HY drafted the work; Wang X and Yang YL collected the data; Zhang YS and Li XJ analyzed and interpreted the data; Zhang YH and Hu TC wrote the article.
Supported byKey R&D Plan of Science and Technology Program of Gansu Province, China, No. 19YF3FH001.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: Dr. Zhang YS reports grants from Key R&D Plan of Science and Technology Program of Gansu Province, China during the conduct of the study.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yan-Shan Zhang, PhD, Chief Doctor, Heavy Ion Center, Wuwei Cancer Hospital, No. 31 Sanitary Lane, Haizang Road, Wuwei 733000, Gansu Province, China. 13830510999@163.com
Received: April 6, 2021 Peer-review started: April 6, 2021 First decision: April 28, 2021 Revised: May 9, 2021 Accepted: July 6, 2021 Article in press: July 6, 2021 Published online: September 16, 2021 Processing time: 156 Days and 20.9 Hours
Abstract
BACKGROUND
Radical cystectomy is considered the first choice for the treatment of muscle-invasive bladder cancer. However, for some patients who have lost the indications for surgery, external beam radiotherapy is a non-invasive and effective treatment.
CASE SUMMARY
A 76-year-old patient with bladder cancer who had serious comorbidities and could not tolerate surgery or chemotherapy came to the Wuwei Heavy Ion Center. He received carbon ion radiotherapy (CIRT) with a whole-bladder dose of 44 GyE and tumor boost of 20 GyE. When he finished CIRT, his bladder cancer-related hematuria completely disappeared, and computed tomography examination showed that the tumor had obviously decreased in size. At the 3-mo follow-up, the tumor disappeared, and there were no acute or late adverse events. CIRT was well tolerated in this patient.
CONCLUSION
CIRT may allow for avoiding resection and was well tolerated with curative outcomes.
Core Tip: This case report is of a bladder cancer patient who received carbon ion radiotherapy (CIRT). The patient tolerated CIRT well. After the completion of CIRT, the hematuria associated with bladder cancer disappeared completely, and computed tomography examination showed that the tumor was significantly reduced. During the 3-mo follow-up, the tumor disappeared and there were no acute or late adverse events.
