Du R, Jiang F, Wang ZY, Kang YQ, Wang XY, Du Y. Pure large cell neuroendocrine carcinoma originating from the endometrium: A case report. World J Clin Cases 2021; 9(14): 3449-3457 [PMID: 34002157 DOI: 10.12998/wjcc.v9.i14.3449]
Corresponding Author of This Article
Ying Du, MM, Doctor, Department of Pathology, Liaocheng People’s Hospital, No. 67 Dongchang West Road, Liaocheng 252000, Shandong Province, China. duying0309@163.com
Research Domain of This Article
Obstetrics & Gynecology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. May 16, 2021; 9(14): 3449-3457 Published online May 16, 2021. doi: 10.12998/wjcc.v9.i14.3449
Pure large cell neuroendocrine carcinoma originating from the endometrium: A case report
Ran Du, Feng Jiang, Zheng-Yan Wang, Yan-Qing Kang, Xiu-Yu Wang, Ying Du
Ran Du, Zheng-Yan Wang, Xiu-Yu Wang, Ying Du, Department of Pathology, Liaocheng People’s Hospital, Liaocheng 252000, Shandong Province, China
Feng Jiang, Department of Thoracic Surgery, Liaocheng Tumor Hospital, Liaocheng 252000, Shandong Province, China
Yan-Qing Kang, Department of Radiology, Liaocheng People’s Hospital, Liaocheng 252000, Shandong Province, China
Author contributions: Du R and Jiang J contributed to the work equally; Du R was a major contributor in reviewing literature and writing the manuscript; Jiang F analyzed and interpreted the patient data; Wang ZY, Wang XY, and Du Y performed the histological examination of the tumor and performed histological diagnosis; Kang YQ analyzed the patient’s magnetic resonance imaging data; All authors read and approved the final manuscript.
Informed consent statement: The present study was approved by the Ethics Committee of Liaocheng People’s Hospital, and written informed consent was obtained from the patient. Written informed consent was obtained from the patient for publication of this case report.
Conflict-of-interest statement: The authors report no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ying Du, MM, Doctor, Department of Pathology, Liaocheng People’s Hospital, No. 67 Dongchang West Road, Liaocheng 252000, Shandong Province, China. duying0309@163.com
Received: December 8, 2020 Peer-review started: December 8, 2020 First decision: January 24, 2021 Revised: February 10, 2021 Accepted: March 4, 2021 Article in press: March 4, 2021 Published online: May 16, 2021 Processing time: 142 Days and 6.8 Hours
Abstract
BACKGROUND
Large cell neuroendocrine carcinoma (LCNEC) of the endometrium is an uncommon and highly aggressive tumor that has not been comprehensively characterized. We report a case of pure endometrial LCNEC and review the current literature of similar cases to raise awareness of the histological features, treatment, and prognosis of this tumor.
CASE SUMMARY
We report the case of a 73-year-old woman who presented with irregular postmenopausal vaginal bleeding. Ultrasonography showed an enlarged uterus and a 5.1 cm × 3.3 cm area of medium and low echogenicity in the uterine cavity. Biopsy by dilatation and curettage suggested poorly differentiated carcinoma. Magnetic resonance imaging revealed a heterogeneously enhanced uterine tumor with diffuse infiltration of the posterior wall of the uterine myometrium and enlarged pelvic lymph nodes. The patient underwent a hysterectomy and bilateral adnexal resection. Gross observation revealed an ill-defined white solid mass of the posterior wall of the uterus infiltrating into the serosa with multiple solid nodules on the serous surface. Microscopically, the tumor cells showed neuroendocrine morphology (organoid nesting). Immunohistochemistry revealed the tumor cells were diffusely positive for the neuroendocrine markers CD56, chromogranin A, and synaptophysin. Thus, the tumor was diagnosed as stage IIIC endometrial LCNEC.
CONCLUSION
Pathologic findings and immunohistochemistry are essential in making a diagnosis of endometrial LCNEC.
Core Tip: We report the diagnostic and therapeutic experience of a 73-year-old patient with pure endometrial large cell neuroendocrine carcinoma. This article explores the histological features, differential diagnosis, treatment, and prognosis of this tumor and reviews the current literature of similar cases to provide a reference for the diagnosis and treatment of endometrial large cell neuroendocrine carcinoma.
