Yin XN, Yin Y, Wang J, Shen CY, Chen X, Zhao Z, Cai ZL, Zhang B. Gastrointestinal stromal tumor metastasis at the site of a totally implantable venous access port insertion: A rare case report. World J Clin Cases 2020; 8(20): 5007-5012 [PMID: 33195674 DOI: 10.12998/wjcc.v8.i20.5007]
Corresponding Author of This Article
Bo Zhang, MD, PhD, Professor, Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, No. 37 Guoxue Lane, Chengdu 610041, Sichuan Province, China. hxwcwk@126.com
Research Domain of This Article
Oncology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Xiao-Nan Yin, Yuan Yin, Jiang Wang, Chao-Yong Shen, Xin Chen, Zhou Zhao, Zhao-Lun Cai, Bo Zhang, Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Author contributions: Zhang B carried out concept design; Yin XN and Yin Y carried out data analysis and wrote the manuscript; Wang J and Shen CY carried out data acquisition and data analysis; Chen X and Zhao Z carried out data acquisition and the literature search; Zhao Z and Cai ZL edited and revised the manuscript; all the authors have read and approved the final manuscript.
Supported bythe National Natural Science Foundation of China, No. 81572931; and 1.3.5 Project for Disciplines of Excellence, West China Hospital, Sichuan University, No. ZYJC18034.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Bo Zhang, MD, PhD, Professor, Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, No. 37 Guoxue Lane, Chengdu 610041, Sichuan Province, China. hxwcwk@126.com
Received: June 21, 2020 Peer-review started: June 21, 2020 First decision: July 24, 2020 Revised: July 28, 2020 Accepted: September 2, 2020 Article in press: September 2, 2020 Published online: October 26, 2020 Processing time: 124 Days and 21.4 Hours
Abstract
BACKGROUND
The totally implantable venous access port (TIVAP) is an important device in patients for injecting blood products, parenteral nutrition or antineoplastic chemotherapy. Metastatic spread at the site of the insertion of a TIVAP is extremely rare.
CASE SUMMARY
We report the case of 33-year-old male with advanced gastrointestinal stromal tumor (GIST) who underwent radical tumor resection after neoadjuvant imatinib therapy. However, a solitary GIST metastasis at the site of a TIVAP insertion developed during adjuvant imatinib treatment. Mutational analysis showed secondary mutation in KIT exon 13 (V564A), which is resistant to imatinib treatment. To our knowledge, this is the first case report of a patient with advanced GIST developing GIST metastasis at the site of a TIVAP insertion.
CONCLUSION
This case highlights that when a patient with advanced, high metastatic GIST requires TIVAP insertion, we should realize that there is a risk of developing tumor metastasis at the site of a TIVAP insertion.
Core Tip: In this article, we report a man with advanced gastrointestinal stromal tumor (GIST) who developed GIST metastasis at the site of a totally implantable venous access port (TIVAP) insertion. This case highlights that when a patient with advanced, high metastatic GIST requires TIVAP insertion, it should be realized that there is a risk of developing tumor metastasis at the site of the TIVAP insertion.
