Rozłucka L, Semik-Grabarczyk E, Pietrukaniec M, Żak-Gołąb A, Grabarczyk M, Grosicki S, Holecki M. Demyelinating polyneuropathy and lymphoplasmacytic lymphoma coexisting in 36-year-old man: A case report. World J Clin Cases 2020; 8(12): 2566-2573 [PMID: 32607333 DOI: 10.12998/wjcc.v8.i12.2566]
Corresponding Author of This Article
Lesia Rozłucka, MD, Doctor, Department of Internal Medicine, Allergology and Clinical Immunology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Medykow 14, Katowice 40-752, Poland. lesia.rozlucka@gmail.com
Research Domain of This Article
Hematology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Jun 26, 2020; 8(12): 2566-2573 Published online Jun 26, 2020. doi: 10.12998/wjcc.v8.i12.2566
Demyelinating polyneuropathy and lymphoplasmacytic lymphoma coexisting in 36-year-old man: A case report
Lesia Rozłucka, Elżbieta Semik-Grabarczyk, Marta Pietrukaniec, Agnieszka Żak-Gołąb, Małgorzata Grabarczyk, Sebastian Grosicki, Michał Holecki
Lesia Rozłucka, Department of Internal Medicine, Allergology and Clinical Immunology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice 40-752, Poland
Elżbieta Semik-Grabarczyk, Marta Pietrukaniec, Agnieszka Żak-Gołąb, Michał Holecki, Department of Internal Medicine, Autoimmune and Metabolic Diseases, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice 40-752, Poland
Małgorzata Grabarczyk, Student Scientific Society at the Department of Internal Medicine, Autoimmune and Metabolic Diseases, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice 40-752, Poland
Sebastian Grosicki, Department of Hematology and Cancer Prevention, Faculty of Health Sciences in Bytom, Medical University of Silesia, Bytom, 41-902, Poland
Author contributions: Rozłucka L was patients’ doctor, drafted and prepared manuscript for final publication; Semik-Grabarczyk E and Grabarczyk M reviewed the literature and drafted the manuscript; Pietrukaniec M and Żak-Gołąb A contributed to manuscript drafting and translated the manuscript; Grosicki S performed hematology consultation and revised the manuscript; Holecki M was responsible for the revision of the manuscript for important intellectual content. All authors issued final approval for the version to be submitted.
Informed consent statement: Informed written consent was obtained from the patient for hospitalization and performing diagnostic procedures.
Conflict-of-interest statement: None of the authors have any potential conflicts of interest to declare regarding this case report.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Lesia Rozłucka, MD, Doctor, Department of Internal Medicine, Allergology and Clinical Immunology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Medykow 14, Katowice 40-752, Poland. lesia.rozlucka@gmail.com
Received: February 24, 2020 Peer-review started: February 24, 2020 First decision: April 24, 2020 Revised: May 20, 2020 Accepted: May 23, 2020 Article in press: May 23, 2020 Published online: June 26, 2020 Processing time: 120 Days and 7.7 Hours
Abstract
BACKGROUND
Lymphoplasmacytic lymphoma is a rare non-Hodgkin’s lymphoma, occurring mostly in the elderly. It develops slowly and leads to malignant proliferation of lymphoid line cells in the bone marrow, lymph nodes and spleen. It may also affect nerve roots and meninges; some patients develop sensorimotor polyneuropathy which may precede general symptoms of lymphoma.
CASE SUMMARY
We present a case of a 36-year-old man diagnosed in 2012 with chronic inflammatory demyelinating polyneuropathy (CIDP), then he was hospitalized in 2019 due to progressive symptoms of heart failure and significant weight loss over the previous four months. Based on clinical and laboratory findings a diagnosis of lymphoplasmacytic lymphoma was suspected and confirmed by bone marrow flow cytometry. There was no improvement in the results of laboratory tests and the patient's condition after immediate implementation of chemotherapy. Patient died on the fifth day of treatment.
CONCLUSION
While CIDP and malignant disease co-occurrence is rare, it should be suspected and investigated in patients with atypical neuropathy symptoms.
Core tip: Lymphoplasmacytic lymphoma is a low-grade B cell type of non-Hodgkin's lymphoma. It occurs mainly in elderly, develops slowly and leads to malignant proliferation of lymphoid line cells in the bone marrow. In some cases, patients develop polyneuropathy, which may precede the general symptoms of lymphoma. We present a case of a young man with chronic inflammatory demyelinating polyneuropathy since 2012. His neurological condition worsened rapidly seven years later, which turned out to be paraneoplastic symptom of aggressive lymphoplasmacytic lymphoma. The lack of typical hematological symptoms resulted in delaying the diagnosis and fatal outcome.
