Zhang SC, Yu MY, Xi L, Zhang JX. Tegafur deteriorates established cardiovascular atherosclerosis in colon cancer: A case report and review of the literature. World J Clin Cases 2019; 7(1): 89-94 [PMID: 30637257 DOI: 10.12998/wjcc.v7.i1.89]
Corresponding Author of This Article
Jie-Xin Zhang, MD, PhD, Associate Professor, Department of Laboratory Medicine, the First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, Jiangsu Province, China. jiexinzhang@njmu.edu.cn
Research Domain of This Article
Medicine, Research & Experimental
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Share the Article
Zhang SC, Yu MY, Xi L, Zhang JX. Tegafur deteriorates established cardiovascular atherosclerosis in colon cancer: A case report and review of the literature. World J Clin Cases 2019; 7(1): 89-94 [PMID: 30637257 DOI: 10.12998/wjcc.v7.i1.89]
World J Clin Cases. Jan 6, 2019; 7(1): 89-94 Published online Jan 6, 2019. doi: 10.12998/wjcc.v7.i1.89
Tegafur deteriorates established cardiovascular atherosclerosis in colon cancer: A case report and review of the literature
Shi-Chang Zhang, Meng-Yao Yu, Lei Xi, Jie-Xin Zhang
Shi-Chang Zhang, Meng-Yao Yu, Jie-Xin Zhang, Department of Laboratory Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China
Lei Xi, Department of Pathology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China
Author contributions: Yu MY and Xi L participated in data collection; Zhang SC and Zhang JX conceived and coordinated the study; all authors participated in manuscript writing.
Supported byNational Natural Science Foundation of China, No. 81501817 and No. 81671836; Natural Science Youth Foundation of Jiangsu Province, No. BK20151029; and the Key Laboratory for Laboratory Medicine of Jiangsu Province of China, No. ZDXKB2016005.
Informed consent statement: Informed consent was obtained from the patient.
Conflict-of-interest statement: We declare that we do not have any commercial or associative interest that represents a conflict of interest in connection with the work submitted.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Corresponding author: Jie-Xin Zhang, MD, PhD, Associate Professor, Department of Laboratory Medicine, the First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, Jiangsu Province, China. jiexinzhang@njmu.edu.cn
Telephone: +86-25-68103450
Received: August 10, 2018 Peer-review started: August 10, 2018 First decision: October 9, 2018 Revised: November 2, 2018 Accepted: November 7, 2018 Article in press: November 7, 2018 Published online: January 6, 2019 Processing time: 147 Days and 7.7 Hours
Abstract
BACKGROUND
Cardiac toxic effect of tegafur (S-1) is extremely rare, and there has been no report on this issue so far.
CASE SUMMARY
We herein report a typical case of single S-1 administration after radical operation for colon cancer. The patient had no background or medical history of acute coronary syndrome (ACS), and only aortic and coronary atherosclerosis was revealed by computed tomography (CT) before surgery. He complained of sternum pain during the fifth cycle of S-1 treatment. Electrocardiogram (ECG) and serum cardiac marker cardiac troponin T (cTnT) strongly suggested ACS, which was possibly caused by S-1 cardiotoxicity.
CONCLUSION
Monitoring protocols based on ECG, CT, and cTnT should be performed in real time to evaluate cardiac function during S-1 administration.
Core tip: Cardiac toxic effect of tegafur (S-1) is extremely rare, and there has been no report on this issue so far. We herein report a typical case and review the literature. The case might contribute to improving our understanding of the pharmacology and mechanism of S-1 in treating colon cancer. This report also emphasizes the group of cancer patients who have already been diagnosed with cardiovascular atherosclerosis and serves as a reminder to gastroenterologists that delicate monitoring protocols should be carried out in real time to evaluate the cardiac function of S-1-onging patients.
