Deng X, Lv LY, Jiang SX, Huang JX, Chen XY, Zhang MF, Qi J, Yang M. Low-grade appendiceal mucinous neoplasm: A case report. World J Clin Cases 2025; 13(34): 111668 [DOI: 10.12998/wjcc.v13.i34.111668]
Corresponding Author of This Article
Man Yang, PhD, Associate Chief Physician, Department of Gastroenterology, The Seventh Affiliated Hospital, Sun Yat-sen University, No. 628 Zhenyuan Road, Shenzhen 518107, Guangdong Province, China. yangman@sysush.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Low-grade appendiceal mucinous neoplasm: A case report
Xi Deng, Li-Yuan Lv, Su-Xiang Jiang, Jian-Xian Huang, Xin-Yuan Chen, Meng-Fei Zhang, Jian Qi, Man Yang
Xi Deng, Li-Yuan Lv, Xin-Yuan Chen, Meng-Fei Zhang, Jian Qi, Man Yang, Department of Gastroenterology, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen 518107, Guangdong Province, China
Su-Xiang Jiang, Department of Imaging, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen 518107, Guangdong Province, China
Jian-Xian Huang, Department of Pathology, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen 518107, Guangdong Province, China
Co-first authors: Xi Deng and Li-Yuan Lv.
Co-corresponding authors: Jian Qi and Man Yang.
Author contributions: Deng X, Lv LY, Chen XY, and Zhang MF contributed to manuscript writing and editing; Deng X and Lv LY contributed equally to this manuscript as co-first authors; Jiang SX and Huang JX contributed to collect and edit images and pathology; Qi J and Yang M contributed to conceptualization and supervision and they contributed equally to this manuscript as co-corresponding authors. All authors have read and approved the final manuscript.
Supported by the National Natural Science Foundation of China, No. 82204123.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Man Yang, PhD, Associate Chief Physician, Department of Gastroenterology, The Seventh Affiliated Hospital, Sun Yat-sen University, No. 628 Zhenyuan Road, Shenzhen 518107, Guangdong Province, China. yangman@sysush.com
Received: July 6, 2025 Revised: August 3, 2025 Accepted: November 20, 2025 Published online: December 6, 2025 Processing time: 152 Days and 21.6 Hours
Abstract
BACKGROUND
Low-grade appendiceal mucinous neoplasms are papillary or flat mucinous tumors with low-grade cytologic atypia. They are the most frequent source of pseudomyxoma peritonei. They can be easily misdiagnosed, due to unspecific symptoms, with acute appendicitis, retroperitoneal tumors or adnexal mass. Cases of huge appendiceal mucinous neoplasms are even more extremely rare.
CASE SUMMARY
We report a 54-year-old patient who presented with a 10-month history of constant dull distension accompanied by nausea. A surgical procedure of total hysterectomy, bilateral adnexectomy, appendectomy, greater omentectomy and right hemicolectomy was performed as a result of the findings on ultrasound, computed tomography scan and magnetic resonance imaging. Diagnosis was made after the pathological examination, which revealed low-grade appendiceal mucinous neoplasm. The patient received hyperthermic intraperitoneal chemotherapy with cisplatin and was discharged from the hospital.
CONCLUSION
Low-grade appendiceal mucinous adenomas are rare tumors that are easily misdiagnosed, and a more thorough clinical workup is required to make a definitive diagnosis.
Core Tip: We report a middle-aged patient who presented with persistent, dull abdominal distension and nausea, with symptoms persisting for 10 months. Imaging studies revealed a space-occupying lesion, and the patient subsequently underwent surgical resection. Histopathological examination confirmed the diagnosis of low-grade appendiceal mucinous neoplasm. Following surgery, the patient received intraperitoneal hyperthermic chemotherapy with cisplatin and was discharged in stable condition.
