Abdeldayem T, Memon S, Omari M, Egred M, Bawamia B, Farag M, Alkhalil M. Thrombectomy in acute myocardial infarction: Current evidence, challenges, and emerging technologies. World J Clin Cases 2025; 13(33): 107990 [PMID: 41356091 DOI: 10.12998/wjcc.v13.i33.107990]
Corresponding Author of This Article
Mohammad Alkhalil, Consultant, Department of Cardiology, Freeman Hospital, Freeman Road, Newcastle NE7 7DU, Newcastle upon Tyne, United Kingdom. mohammad.alkhalil@nhs.net
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Cardiac & Cardiovascular Systems
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Minireviews
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Nov 26, 2025 (publication date) through Jan 15, 2026
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World Journal of Clinical Cases
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2307-8960
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Abdeldayem T, Memon S, Omari M, Egred M, Bawamia B, Farag M, Alkhalil M. Thrombectomy in acute myocardial infarction: Current evidence, challenges, and emerging technologies. World J Clin Cases 2025; 13(33): 107990 [PMID: 41356091 DOI: 10.12998/wjcc.v13.i33.107990]
World J Clin Cases. Nov 26, 2025; 13(33): 107990 Published online Nov 26, 2025. doi: 10.12998/wjcc.v13.i33.107990
Thrombectomy in acute myocardial infarction: Current evidence, challenges, and emerging technologies
Tarek Abdeldayem, Saif Memon, Muntaser Omari, Mohaned Egred, Bilal Bawamia, Mohamed Farag, Mohammad Alkhalil
Tarek Abdeldayem, Saif Memon, Muntaser Omari, Mohaned Egred, Bilal Bawamia, Mohamed Farag, Mohammad Alkhalil, Department of Cardiology, Freeman Hospital, Newcastle upon Tyne NE7 7DN, United Kingdom
Author contributions: Abdeldayem T contributed to data collection, first draft, review and edit final draft; Memon S, Omari M contributed to data collection, review and edit the final draft; Egred M, Bawamia B, Farag M contributed to supervision, resources, review and edit the final draft; Alkhalil M contributed to conceptualization, first draft, supervision, resources, review and edit the final draft.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Mohammad Alkhalil, Consultant, Department of Cardiology, Freeman Hospital, Freeman Road, Newcastle NE7 7DU, Newcastle upon Tyne, United Kingdom. mohammad.alkhalil@nhs.net
Received: April 2, 2025 Revised: May 1, 2025 Accepted: October 16, 2025 Published online: November 26, 2025 Processing time: 233 Days and 11.1 Hours
Abstract
Thrombus burden significantly increases risk of no-reflow and microvascular obstruction and subsequently impacts outcomes in acute myocardial infarction (AMI). While initial studies suggested benefits of thrombus aspiration (TA), recent large trials have questioned its routine use. This review examines the role of thrombectomy in the management of AMI, focusing on its potential to improve myocardial perfusion and mitigate no-reflow risk. Attention should be focused on recognising high thrombus burden and its effect on major adverse cardiovascular events and impaired myocardial reperfusion. Similarly, standardising TA techniques and ensuring appropriate patients’ selection may also improve enhance our understanding of the role of thrombectomy in AMI. Emerging technologies such as stent retrievals and mechanical thrombectomy may overcome the limitations of manual thrombectomy devices.
Core Tip: Thrombus aspiration during acute myocardial infarction (AMI) is a debatable subject. Previous studies highlighted its inefficacy when it is performed routinely. Several limitations were recognised, and studies neutral results may be related to the used device rather determining the efficacy of thrombectomy as concept. Emerging technology and optimal patient selection may allow addressing the role of thrombectomy in AMI.
