Verma AK, Vats Y, Bajpai J, Kar SK, Pradhan A, Kant S. Pulmonary tuberculosis in diabetes: Exploring the intersection and impact on mental health. World J Clin Cases 2025; 13(32): 110154 [DOI: 10.12998/wjcc.v13.i32.110154]
Corresponding Author of This Article
Akshyaya Pradhan, Department of Cardiology, King George's Medical University, Shahmina Road, Chowk, Lucknow 226003, Uttar Pradesh, India. akshyaya33@gmail.com
Research Domain of This Article
Respiratory System
Article-Type of This Article
Minireviews
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Nov 16, 2025 (publication date) through Nov 15, 2025
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Journal Information of This Article
Publication Name
World Journal of Clinical Cases
ISSN
2307-8960
Publisher of This Article
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Verma AK, Vats Y, Bajpai J, Kar SK, Pradhan A, Kant S. Pulmonary tuberculosis in diabetes: Exploring the intersection and impact on mental health. World J Clin Cases 2025; 13(32): 110154 [DOI: 10.12998/wjcc.v13.i32.110154]
Ajay Kumar Verma, Yogita Vats, Jyoti Bajpai, Surya Kant, Department of Respiratory Medicine, King George's Medical University, Lucknow 226003, Uttar Pradesh, India
Sujita Kumar Kar, Department of Psychiatry, King George's Medical University, Lucknow 226003, Uttar Pradesh, India
Akshyaya Pradhan, Department of Cardiology, King George's Medical University, Lucknow 226003, Uttar Pradesh, India
Co-first authors: Ajay Kumar Verma and Yogita Vats.
Co-corresponding authors: Jyoti Bajpai and Akshyaya Pradhan.
Author contributions: Verma AK, Vats Y and Bajpai J conceived the project; Kar SK and Pradhan A performed the literature search; Verma AK, Kar SK and Vats Y prepared the first draft; Bajpai J and Kar SK critically reviewed it; Pradhan A and Kant S prepared the final manuscript and uploaded it; Bajpai J and Vats Y revised the manuscript; Pradhan A was responsible for submitting the revised version; Bajpai J and Pradhan A have played important and indispensable roles in the manuscript preparation as the co-corresponding authors.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Akshyaya Pradhan, Department of Cardiology, King George's Medical University, Shahmina Road, Chowk, Lucknow 226003, Uttar Pradesh, India. akshyaya33@gmail.com
Received: May 30, 2025 Revised: June 14, 2025 Accepted: September 23, 2025 Published online: November 16, 2025 Processing time: 166 Days and 18.4 Hours
Abstract
There is a bidirectional association between type II diabetes mellitus (T2DM) and pulmonary tuberculosis (PTB), with each enhancing the risk of the other, thus increasing the burden of both drug-sensitive and drug-resistant forms of the disease. This dual burden also has a detrimental impact on patient's mental health. Although several recommendations have been made for bidirectional screening of diabetes and tuberculosis, implementation remains poor, resulting in increased morbidity and mortality among patients with this comorbidity. Mental health is often neglected, as clinical outcomes receive disproportionate focus, with limited attention to patients’ social and psychological well-being. According to the World Health Organization, health is defined as a state of physical, mental, and social well-being, and not merely the absence of disease or infirmity. The aim of this mini-review is to highlight the intersection of PTB and T2DM, specifically discussing the mental health outcomes of the co-burden.
Core Tip: Pulmonary tuberculosis (PTB) and Diabetes Mellitus type 2 (T2DM) both significantly increase the risk of mental health disorders, particularly depression and anxiety. Mental health issues in PTB patients are often underdiagnosed and undertreated, which can negatively affect treatment outcomes. Early screening and integrated care for mental health within co-morbid PTB and T2DM treatment programs are crucial for patient recovery. Stigma, social isolation, and financial burdens contribute to the psychological distress experienced by PTB patients with T2DM. Multidisciplinary approaches involving mental health professionals are essential for the holistic management of PTB.
