Rahmoune H, Boutrid N. Clots in colitis: Thromboembolism and beyond. World J Clin Cases 2025; 13(26): 102957 [DOI: 10.12998/wjcc.v13.i26.102957]
Corresponding Author of This Article
Hakim Rahmoune, MD, Assistant Professor, Department of Medicine, LIRSSEI Research Laboratory, Faculty of Medicine, University of Setif-1, Voie Rapide Setif-Bordj Bou Arreridj, Setif 19000, Algeria. rahmounehakim@gmail.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Sep 16, 2025; 13(26): 102957 Published online Sep 16, 2025. doi: 10.12998/wjcc.v13.i26.102957
Clots in colitis: Thromboembolism and beyond
Hakim Rahmoune, Nada Boutrid
Hakim Rahmoune, Department of Medicine, LIRSSEI Research Laboratory, Faculty of Medicine, University of Setif-1, Setif 19000, Algeria
Hakim Rahmoune, Department of Pediatrics, Setif University Hospital, University of Setif-1, Setif 19000, Algeria
Nada Boutrid, LIRSSEI Research Laboratory, Faculty of Medicine, University of Setif-1, Setif 19000, Algeria
Author contributions: Rahmoune H was responsible for data curation; Boutrid N was responsible for supervision and validation; Rahmoune H and Boutrid N were responsible for conceptualization, writing original draft, review and editing; all of the authors read and approved the final version of the manuscript to be published.
Conflict-of-interest statement: All authors declare no conflict of interest in publishing the manuscript.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hakim Rahmoune, MD, Assistant Professor, Department of Medicine, LIRSSEI Research Laboratory, Faculty of Medicine, University of Setif-1, Voie Rapide Setif-Bordj Bou Arreridj, Setif 19000, Algeria. rahmounehakim@gmail.com
Received: November 19, 2024 Revised: April 5, 2025 Accepted: June 3, 2025 Published online: September 16, 2025 Processing time: 246 Days and 15.7 Hours
Abstract
Patients with ulcerative colitis (UC) have an increased risk of thromboembolic events, particularly venous thromboembolism (VTE), which encompasses deep vein thrombosis and pulmonary embolism. The incidence of VTE in patients with UC is significantly higher than that in the general population, and a retrospective cohort study found that patients undergoing colectomy had a notable risk of developing VTE, with rates reaching as high as 22% among patients exposed to tofacitinib within a month prior to surgery. The GETAID FOCUS study also reported a high prevalence of self-reported VTE in patients with UC, with a pooled prevalence of approximately 12% across various studies. The risk of thromboembolism in UC is multifactorial and influenced by chronic inflammation, a wide range of medications used, potential surgical interventions, and possibly genetic factors or associations that are yet to be fully defined. Recognizing the various contributing factors is crucial for developing effective preventive strategies and improving patient outcomes.
Core Tip: Patients with ulcerative colitis face a significantly increased risk of thromboembolic events, particularly venous thromboembolism (VTE), compared to the general population. This study emphasizes the multifactorial nature of this risk, influenced by chronic inflammation, medication use, surgical interventions, and potential genetic factors. Additionally, the incidence of VTE varies based on geographical and ethnic/racial factors, highlighting the need for tailored preventive strategies and proactive interventions aimed at reducing morbidity associated with these complications.
