Okasha HH, Tag-Adeen M, Shaaban HE. Role of pancreatic juice cytology in diagnosis of high-grade pancreatic intraepithelial neoplasia. World J Clin Cases 2025; 13(10): 94437 [DOI: 10.12998/wjcc.v13.i10.94437]
Corresponding Author of This Article
Hossam Eldin Shaaban, MD, PhD, Department of Internal Medicine and Gastroenterology, National Hepatology and Tropical Medicine Research Institute, No. 10 Kasr Alainy Street, Cairo 11796, Egypt. hsshaaban@aol.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Letter to the Editor
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Apr 6, 2025; 13(10): 94437 Published online Apr 6, 2025. doi: 10.12998/wjcc.v13.i10.94437
Role of pancreatic juice cytology in diagnosis of high-grade pancreatic intraepithelial neoplasia
Hussein Hassan Okasha, Mohammed Tag-Adeen, Hossam Eldin Shaaban
Hussein Hassan Okasha, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kasr Al-Aini School of Medicine, Cairo University, Cairo 11562, Egypt
Mohammed Tag-Adeen, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Qena Faculty of Medicine, South Valley University, Qena 83523, Egypt
Hossam Eldin Shaaban, Department of Internal Medicine and Gastroenterology, National Hepatology and Tropical Medicine Research Institute, Cairo 11796, Egypt
Author contributions: Shaaban HE generated the idea and wrote the provisional draft; Tag-Adeen M and Okasha HH revised the manuscript; and all authors revised the final manuscript prior to submission.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hossam Eldin Shaaban, MD, PhD, Department of Internal Medicine and Gastroenterology, National Hepatology and Tropical Medicine Research Institute, No. 10 Kasr Alainy Street, Cairo 11796, Egypt. hsshaaban@aol.com
Received: March 18, 2024 Revised: November 5, 2024 Accepted: December 3, 2024 Published online: April 6, 2025 Processing time: 275 Days and 3.8 Hours
Abstract
High-grade pancreatic intraepithelial neoplasia is a challenging diagnosis and it does not exhibit mass lesions. It is suspected based on changes in the main pancreatic duct in magnetic resonance cholangiopancreatography. Sometimes only an unclear duct shows in magnetic resonance cholangiopancreatography with no focal strictures and upstream dilatation of the main pancreatic duct. Serial pancreatic juice cytology is valuable in diagnosis of those patients.
Core Tip: Early diagnosis of pancreatic ductal adenocarcinoma may be challenging. The tumor may start with pancreatic intraepithelial neoplasia, that when detected, could be an opportunity for an early curative surgery. Serial pancreatic juice cytology is a valuable diagnostic modality in high-grade intraepithelial neoplasia of the pancreas, especially in cases with unclear main pancreatic duct without focal strictures and dilatation.
