Published online Mar 16, 2024. doi: 10.12998/wjcc.v12.i8.1442
Peer-review started: November 13, 2023
First decision: January 9, 2024
Revised: January 15, 2024
Accepted: February 18, 2024
Article in press: February 18, 2024
Published online: March 16, 2024
Processing time: 119 Days and 21.7 Hours
Immature ovarian teratoma is a rare and aggressive neoplasm that affects young women. This report is the first to describe the development of immature teratoma after ovarian cystectomy for mature teratoma of the ovary in an adolescent female with a family history of ovarian teratoma.
A 16-year-old girl who had undergone bilateral ovarian cystectomy for mature teratomas 3 years ago showed bilateral adnexal tumors during her regular ultrasonography follow-up every 6 months. She received laparoscopic bilateral ovarian cystectomy, and final histopathology showed grade-1 immature teratoma of the left ovary and mature teratoma of the right ovary. Laparoscopic left salpingo-oophorectomy and staging procedures were performed again. Her mother, maternal aunt, and maternal grandmother had also received surgeries for mature ovarian teratomas.
It is important to have guidance on management of patient and family members with familial ovarian teratomas.
Core Tip: This report describes a unique case of an adolescent woman with familial ovarian teratoma that was initially diagnosed as mature ovarian teratoma and later recurred and identified as immature ovarian teratoma during follow-up. Our case highlights the importance of genetic counseling, screening, and close surveillance in families with a predisposition to ovarian teratomas. Collaborative efforts between oncologists, geneticists, and researchers are necessary to determine the underlying mechanisms and develop targeted interventions for individuals at high risk of immature teratomas.