Case Report
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Mar 6, 2024; 12(7): 1333-1338
Published online Mar 6, 2024. doi: 10.12998/wjcc.v12.i7.1333
Heterochronous multiple primary prostate cancer and lymphoma: A case report
Jin-Long Liang, Yu-Qing Bu, Li-Li Peng, Hong-Zhen Zhang
Jin-Long Liang, Yu-Qing Bu, Li-Li Peng, Hong-Zhen Zhang, Department of Oncology, Hebei General Hospital, Shijiazhuang 050051, Hebei Province, China
Author contributions: Liang JL wrote the article; Bu YQ collected the literature; Peng LL revised the format of the article; Zhang HZ revised and is responsible for the full text.
Supported by Key Research and Development Projects in Hebei Province, No. 21377795D; and Natural Science Foundation of Hebei Province, No. H2021307017.
Informed consent statement: We have obtained the informed consent of the patient's family.
Conflict-of-interest statement: There is no conflict of interest in this report.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hong-Zhen Zhang, PhD, Doctor, Department of Oncology, Hebei General Hospital, No. 348 Heping West Road, Xinhua District, Shijiazhuang 050051, Hebei Province, China. 1256596529@qq.com
Received: November 12, 2023
Peer-review started: November 12, 2023
First decision: January 9, 2024
Revised: January 17, 2024
Accepted: February 6, 2024
Article in press: February 6, 2024
Published online: March 6, 2024
Processing time: 109 Days and 23.7 Hours
Abstract
BACKGROUND

Multiple primary malignant tumors (MPMTs) are rare type of cancer, especially when solid tumors are the first and lymphoma is the second primary malignancy. We report a patient with heterochronous MPMTs consisting of prostate cancer and rectal diffuse large B-cell lymphoma (DLBCL).

CASE SUMMARY

We report a 77-year-old male patient diagnosed with prostate cancer who was treated with radiation therapy and one year of endocrine therapy with bicalutamide (50 mg per day) and an extended-release implant of goserelin (1/28 d). Seven years later, rectal DLBCL with lung metastases was found.

CONCLUSION

Although rare, the possibility of prostate cancer combined with a double primary cancer of DLBCL can provide a deeper understanding.

Keywords: Multiple primary malignant tumors; Radiation therapy; Diffuse large B-cell lymphoma; Prostate cancer; Non-Hodgkin lymphoma; Case report

Core Tip: We report the case of a 77-year-old male patient diagnosed with prostate cancer presenting with dysuria with hematuria. He received radiation therapy and 1 year of endocrine therapy with an efficacy evaluation of partial response. 7 years later, he was diagnosed with diffuse large B-cell lymphoma of the rectum with lung metastases presenting with lower abdominal pain and constipation, and was treated with 2 cycles of chemotherapy on the CHOP regimen with an efficacy evaluation of remission. He was not treated again for personal reasons and unfortunately, the patient died 1 year later.