Heterochronous multiple primary prostate cancer and lymphoma: A case report

Abstract

BACKGROUND

Multiple primary malignant tumors (MPMTs) are rare type of cancer, especially when solid tumors are the first and lymphoma is the second primary malignancy. We report a patient with heterochronous MPMTs consisting of prostate cancer and rectal diffuse large B-cell lymphoma (DLBCL).

CASE SUMMARY

We report a 77-year-old male patient diagnosed with prostate cancer who was treated with radiation therapy and one year of endocrine therapy with bicalutamide (50 mg per day) and an extended-release implant of goserelin (1/28 d). Seven years later, rectal DLBCL with lung metastases was found.

CONCLUSION

Although rare, the possibility of prostate cancer combined with a double primary cancer of DLBCL can provide a deeper understanding.

Keywords: Multiple primary malignant tumors; Radiation therapy; Diffuse large B-cell lymphoma; Prostate cancer; Non-Hodgkin lymphoma; Case report

Core Tip: We report the case of a 77-year-old male patient diagnosed with prostate cancer presenting with dysuria with hematuria. He received radiation therapy and 1 year of endocrine therapy with an efficacy evaluation of partial response. 7 years later, he was diagnosed with diffuse large B-cell lymphoma of the rectum with lung metastases presenting with lower abdominal pain and constipation, and was treated with 2 cycles of chemotherapy on the CHOP regimen with an efficacy evaluation of remission. He was not treated again for personal reasons and unfortunately, the patient died 1 year later.