Jang HR, Lee K, Lim KH. Rare primary gastric peripheral T-cell lymphoma not otherwise specified: A case report. World J Clin Cases 2024; 12(35): 6834-6839 [DOI: 10.12998/wjcc.v12.i35.6834]
Corresponding Author of This Article
Kyu-Hyoung Lim, MD, PhD, Professor, Division of Hematology and Oncology, Department of Internal Medicine, Kangwon National University Hospital, Kangwon National University College of Medicine, 156 Baengnyeong-ro, Chuncheon 24341, South Korea. kyuhyoung.lim@kangwon.ac.kr
Research Domain of This Article
Oncology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Dec 16, 2024; 12(35): 6834-6839 Published online Dec 16, 2024. doi: 10.12998/wjcc.v12.i35.6834
Rare primary gastric peripheral T-cell lymphoma not otherwise specified: A case report
Hee Ryeong Jang, Kyungyul Lee, Kyu-Hyoung Lim
Hee Ryeong Jang, Kyu-Hyoung Lim, Division of Hematology and Oncology, Department of Internal Medicine, Kangwon National University Hospital, Kangwon National University College of Medicine, South Korea
Kyungyul Lee, Department of Pathology, Pathology Center, Seegene Medical Foundation, Seoul 61743, South Korea
Author contributions: Jang HR organized the data and drafted the manuscript; Lee K contributed to writing and reviewing the pathology findings; Lim KH designed the study and contributed to the manuscript writing; all of the authors read and approved the final version of the manuscript to be published.
Supported by2024 Kangwon National University Hospital Grant, No. KNUH_2024_02_06.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Kyu-Hyoung Lim, MD, PhD, Professor, Division of Hematology and Oncology, Department of Internal Medicine, Kangwon National University Hospital, Kangwon National University College of Medicine, 156 Baengnyeong-ro, Chuncheon 24341, South Korea. kyuhyoung.lim@kangwon.ac.kr
Received: June 21, 2024 Revised: August 21, 2024 Accepted: September 13, 2024 Published online: December 16, 2024 Processing time: 125 Days and 7.8 Hours
Abstract
BACKGROUND
Gastrointestinal lymphoma typically arises in the stomach, small bowel, or colorectum and is usually a B-cell lymphoma. However, primary T-cell lymphomas originating in the stomach are particularly rare. Gastric peripheral T-cell lymphoma-not otherwise specified (PTCL-NOS) is an extremely rare subtype.
CASE SUMMARY
We report a 63-year-old male presenting with epigastric pain. Esophagogastroduodenoscopy revealed a large ulcerative lesion in the gastric cardia. Biopsy and immunohistochemical profiling confirmed PTCL-NOS. Imaging indicated stage II disease involving the stomach and intra-abdominal lymph nodes. The patient is planned to undergo cyclophosphamide, doxorubicin, vincristine, and prednisone or cyclophosphamide, doxorubicin, vincristine, prednisone, and etoposide chemotherapy.
CONCLUSION
This case highlights the necessity of considering PTCL-NOS in differential diagnoses of gastric lesions. Comprehensive histopathological and immunohistochemical analysis is crucial for accurate diagnosis and guiding treatment.
Core Tip: Gastrointestinal lymphoma is an extranodal malignancy primarily arising in the stomach, small intestine, or colorectum, most commonly presenting as B-cell lymphoma. In contrast, primary T-cell lymphomas of the stomach are exceedingly rare, particularly within the spectrum of T-cell lymphoma subtypes. Among these, gastric peripheral T-cell lymphoma-not otherwise specified (PTCL-NOS) is extremely rare. In this report, we present a rare case of a 63-year-old male diagnosed with gastric PTCL-NOS, along with a detailed examination of the clinicopathological features.
