Published online Oct 16, 2024. doi: 10.12998/wjcc.v12.i29.6285
Revised: July 31, 2024
Accepted: August 14, 2024
Published online: October 16, 2024
Processing time: 51 Days and 6.9 Hours
Delayed post hypoxic leukoencephalopathy syndrome (DPHLS), also known as Grinker’s myelinopathy, is a rare but significant neurological condition that mani
To consolidate current knowledge on pathophysiology, clinical features, diag
Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyzes guidelines, we systematically searched PubMed, ScienceDirect and Hinari databases using terms related to delayed post-hypoxic leukoencepha
A total of 73 cases were reviewed. Common comorbidities included schizo
DPHLS remains a complex and multifaceted condition with various etiologies and clinical manifestations. Early recognition and appropriate management are crucial to improving patient outcomes. Future research should focus on standardizing diagnostic criteria, using advanced imaging techniques, and exploring therapeutic interventions to improve understanding and treatment of DPHLS. Conducting prospective cohort studies and developing bio
Core Tip: Delayed post hypoxic leukoencephalopathy syndrome (DPHLS) manifests days to weeks after a hypoxic event, presenting with neurological and cognitive deficits. This systematic review consolidates current knowledge on DPHLS, highlighting the complexity of its pathophysiology and the challenges in diagnosis and treatment. Common causes include benzodiazepine and opioid overdose, and carbon monoxide (CO) poisoning. Neuroimaging typically shows diffuse T2 hyperintensities in cerebral white matter sometimes involving subcortical structures such as the basal ganglia and thalamus. Early recognition and supportive management are crucial. Hyperbaric oxygen therapy may be beneficial in CO poisoning.