Sun Q, Liu XY, Zhang Q, Jiang H. Non-retroareolar male mucinous breast cancer without gynecomastia development in an elderly man: A case report. World J Clin Cases 2023; 11(25): 5954-5961 [PMID: 37727495 DOI: 10.12998/wjcc.v11.i25.5954]
Corresponding Author of This Article
Qiang Sun, PhD, Chief Doctor, Department of Breast Surgery, General Hospital of Benxi Iron & Steel Industry Group of Liaoning Health Industry Group, No. 29 Renming Road, Benxi 117000, Liaoning Province, China. sq1338@hotmail.com
Research Domain of This Article
Oncology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Sep 6, 2023; 11(25): 5954-5961 Published online Sep 6, 2023. doi: 10.12998/wjcc.v11.i25.5954
Non-retroareolar male mucinous breast cancer without gynecomastia development in an elderly man: A case report
Qiang Sun, Xu-Yan Liu, Qi Zhang, Hai Jiang
Qiang Sun, Qi Zhang, Hai Jiang, Department of Breast Surgery, General Hospital of Benxi Iron & Steel Industry Group of Liaoning Health Industry Group, Benxi 117000, Liaoning Province, China
Xu-Yan Liu, Department of Pathology, General Hospital of Benxi Iron & Steel Industry Group of Liaoning Health Industry Group, Benxi 117000, Liaoning Province, China
Author contributions: Sun Q designed the proposal and drafted the manuscript; Liu XY participated in immunohistochemical stain and analysis; Jiang H and Sun Q carried out the ultrasound analysis; Sun Q participated in data collection; Sun Q, Zhang Q, Liu XY, and Jiang H participated in total data analysis; and all authors read and approved the final manuscript.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Qiang Sun, PhD, Chief Doctor, Department of Breast Surgery, General Hospital of Benxi Iron & Steel Industry Group of Liaoning Health Industry Group, No. 29 Renming Road, Benxi 117000, Liaoning Province, China. sq1338@hotmail.com
Received: May 5, 2023 Peer-review started: May 5, 2023 First decision: June 12, 2023 Revised: June 30, 2023 Accepted: August 9, 2023 Article in press: August 9, 2023 Published online: September 6, 2023 Processing time: 118 Days and 19.7 Hours
Abstract
BACKGROUND
Male breast cancer (MBC) is an extremely rare condition and accounts for less than 1% of all breast cancers, and malignant tumors occur in less than 1% of the affected men. Mucinous breast cancer is extremely rare and accounts for 2% of all invasive breast cancers. Generally, MBC is accompanied by a retroareolar mass.
CASE SUMMARY
Herein, we report a case of male mucinous breast carcinoma (MMBC) without gynecomastia development and with mass localization outside the common retroareolar region, wherein the mass was a painless nodule in the right breast of a 64-year-old man. We also discuss the clinical and pathological characteristics of this unusual tumor. The excised breast specimen showed pure mucinous carcinoma. The patient had strong expression of estrogen and progesterone receptors, a low Ki-67 proliferation index of the tumor cells, and negative pathological axillary lymph nodes. The patient underwent modified radical mastectomy and axillary lymph node dissection, followed by tamoxifen hormone therapy.
CONCLUSION
To the best of our knowledge, this is the first case report of MMBC in the non-retroareolar region of the nipple without gynecomastia development. Mucinous tumors are easily missed during diagnosis, and the incidence of axillary lymph node metastases of chest mucinous tumors has increased.
Core Tip: We not only report a rare case, but also discuss the clinical and pathological characteristics of this unusual tumor. Though a summary of a limited number of cases and a comparison with female breast cancer, we reveal some interesting features of male mucinous breast cancer. It is helpful to distinguish the rare male disease.
